The serum metabolome of COVID-19 patients is distinctive and predictive

D Shi, R Yan, L Lv, H Jiang, Y Lu, J Sheng, J Xie, W Wu… - Metabolism, 2021 - Elsevier
… In summary, the serum metabolism of patients with COVID-19 changed specifically and
reflected the influence of the lung, liver, intestine and kidney on the disease. These findings are …

[HTML][HTML] The serum metabolome of moderate and severe COVID-19 patients reflects possible liver alterations involving carbon and nitrogen metabolism

M Caterino, M Costanzo, R Fedele, A Cevenini… - International Journal of …, 2021 - mdpi.com
… The activated immune cells draw on glycolytic metabolism and the lactate converted during
… of COVID-19 [25,26]. In the present study, the serum obtained from a cohort of COVID-19

Identification of serum metabolites enhancing inflammatory responses in COVID-19

CS Zhang, B Zhang, M Li, X Wei, K Gong, Z Li… - Science China Life …, 2022 - Springer
… spectrometry to analyze serum metabolome and lipidome in COVID-19 patients at … metabolites
(of 1,039) were significantly altered in COVID-19 patients. Among them, two metabolites, …

[HTML][HTML] Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

N Xiao, M Nie, H Pang, B Wang, J Hu, X Meng… - Nature …, 2021 - nature.com
… host metabolism correlates with CRS in COVID-19 patients, we performed both metabolomics
and cytokine profiling on serum samples from the same symptomatic COVID-19COVID-19

[HTML][HTML] Using an untargeted metabolomics approach to analyze serum metabolites in COVID-19 patients with nucleic acid turning negative

W Chen, M Yao, M Chen, Z Ou, Q Yang, Y He… - Frontiers in …, 2022 - frontiersin.org
… of COVID-19 … in COVID-19 patients following treatment. The current project pursues rigorously
to characterize the variation of serum metabolites between healthy controls and COVID-19

[HTML][HTML] COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

T Thomas, D Stefanoni, JA Reisz, T Nemkov… - JCI insight, 2020 - ncbi.nlm.nih.gov
… In addition, all patients with COVID-19 in this study exhibited some degree of renal
dysfunction, which may affect serum metabolism by compromising metabolite filtration capacity. …

[HTML][HTML] Quantitative serum NMR spectroscopy stratifies COVID-19 patients and sheds light on interfaces of host metabolism and the immune response with cytokines …

T Rössler, G Berezhnoy, Y Singh, C Cannet… - Metabolites, 2022 - mdpi.com
… (NMR) spectroscopy serum analysis of metabolites, … COVID-19 in a large (534 patient
samples, 305 controls) outpatient cohort of recently tested PCR-positive patients. The COVID-19

[HTML][HTML] Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome

I Roberts, M Wright Muelas, JM Taylor, AS Davison… - Metabolomics, 2022 - Springer
… in the planning of COVID-19 patient treatment. … metabolism and tryptophan metabolism.
A number of these are in accordance with recently published studies comparing COVID-19

[HTML][HTML] Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

JC Páez-Franco, J Torres-Ruiz, VA Sosa-Hernández… - Scientific reports, 2021 - nature.com
… We identified the main changes in serum metabolites associated with severe (n = 46) and
mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The …

[HTML][HTML] Vitamin D metabolites and clinical outcome in hospitalized COVID-19 patients

S Zelzer, F Prüller, P Curcic, Z Sloup, M Holter… - Nutrients, 2021 - mdpi.com
… 25(OH)D may not reliably indicate an impaired vitamin D metabolism. Furthermore, 25(OH)…
The present study provides novel insights in the vitamin D metabolism of COVID-19 patients …