The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options

S Choudhary, K Sharma, O Silakari - Microbial pathogenesis, 2021 - Elsevier
signaling pathways and cytokine storm are crucial factors that lead to acute respiratory
distress syndrome (ARDS) in COVID-19 … with the mortality of COVID-19 patients. Both the …

Targeting multiple signal transduction pathways of SARS-CoV-2: Approaches to COVID-19 therapeutic candidates

S Fakhri, Z Nouri, SZ Moradi, EK Akkol, S Piri… - Molecules, 2021 - mdpi.com
… ], inflammation [18,19], and some host factors [… signaling pathways involved in the pathogenesis
of SARS-CoV-2. In the present review, we describe the dysregulated signaling pathways

SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19

DAB Rex, S Dagamajalu, RK Kandasamy… - … and Signaling, 2021 - Springer
… of signaling molecules will be helpful for COVID-19 research. Therefore, we developed the
signaling pathway … This integrated signaling pathway map of SARS-CoV-2 consists of 326 …

Identification of key signaling pathways induced by SARS-CoV2 that underlie thrombosis and vascular injury in COVID-19 patients

AJ Maxwell, J Ding, Y You, Z Dong… - Journal of Leucocyte …, 2021 - academic.oup.com
… An alarming number of cases have arisen where COVID-19 patients develop complications
… complications that have been associated with COVID-19 and determined that a specific …

Targeting the renin− angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges

K Sriram, R Loomba, PA Insel - Proceedings of the National …, 2020 - National Acad Sciences
… −angiotensin signaling (RAS) pathway in COVID-19 and the targeting of this pathway for
therapeutic … 7) Might other RAS pathway components besides ACE and AGTR1 be targeted for …

Activation of STAT3 signaling pathway in the kidney of COVID-19 patients

F Salem, XZ Li, J Hindi, NM Casablanca, F Zhong… - Journal of …, 2022 - Springer
… NF-kB has been considered as a therapeutic target for COVID-19 patients [17]. Therefore,
we evaluated whether the NF-kB pathway was activated in the kidney of COVID-19 patients. p-…

The role and therapeutic potential of NF-kappa-B pathway in severe COVID-19 patients

A Hariharan, AR Hakeem, S Radhakrishnan… - …, 2021 - Springer
… Camostat Mesylate and nafamostat mesylate are serine protease inhibitors used to treat
pancreatitis and inflammatory diseases could be used to combat NF-κB signalling pathway. …

Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19

KK Oh, M Adnan, DH Cho - Scientific reports, 2021 - nature.com
… of Genes and Genomes) pathway enrichment analysis of … analysis exhibited 26
signaling pathways against COVID-19. … signaling pathway was identified as the key anti-COVID-19

IL-6 signalling pathway inactivation with siltuximab in patients with COVID-19 respiratory failure: an observational cohort study

G Gritti, F Raimondi, D Ripamonti, I Riva, F Landi… - Medrxiv, 2020 - medrxiv.org
… targeting the IL-6 signalling pathway has been identified as a … hyperinflammation associated
with COVID-19. However, to … target the IL-6 signalling pathway in patients with COVID-19. …

Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review

A Yarmohammadi, M Yarmohammadi, S Fakhri… - European journal of …, 2021 - Elsevier
… roles in COVID-19 complications. So… signaling pathways of SARS-CoV-2. Several therapeutic
targets and treatment strategies have also been provided in an attempt to tackle COVID-19