[HTML][HTML] COVID-19: immunopathogenesis and Immunotherapeutics

L Yang, S Liu, J Liu, Z Zhang, X Wan… - Signal transduction and …, 2020 - nature.com
… Thus, targeting the IL-6/IL-6 receptor (IL-6R) signaling pathway is a promising strategy for
relieving inflammation symptoms. Tocilizumab, a humanized anti-IL-6 receptor antibody, has …

[HTML][HTML] Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method

G Taheri, M Habibi - Applied Soft Computing, 2022 - Elsevier
signaling pathways of the host protein which could help to identify effective COVID-19 treatment…
networks corresponding to the COVID-19 related signaling and disease pathways. Then, …

[HTML][HTML] A comprehensive evaluation of the immune system response and type-I Interferon signaling pathway in hospitalized COVID-19 patients

MS Soltani-Zangbar, F Parhizkar, E Ghaedi… - … and Signaling, 2022 - Springer
… The COVID-19 pandemic has become the world’s main life-… and IFN-I signaling pathways
of COVID-19 patients with mild … IFN-I signaling pathway of COVID-19 patients with severe …

The anti-COVID-19 drug remdesivir promotes oncogenic herpesvirus reactivation through regulation of intracellular signaling pathways

J Chen, L Dai, S Kendrick, SR Post… - Antimicrobial agents and …, 2022 - Am Soc Microbiol
signaling pathways (7), respectively, raising a concern about using these drugs in COVID-19
Therefore, it is meaningful to investigate the impact of anti-COVID-19 drugs on chronic viral …

[HTML][HTML] Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19

R Li, K Wu, Y Li, X Liang, WKF Tse, L Yang… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
… might regulate a series of signaling pathways related to viral … in many important cell signaling
pathways such as FoxO, … T cell receptor signaling pathway, leukocyte transendothelial …

[HTML][HTML] A scheme for inferring viral-host associations based on codon usage patterns identifies the most affected signaling pathways during COVID-19

JK Das, S Chakraborty, S Roy - Journal of Biomedical Informatics, 2021 - Elsevier
… different human cellular signaling pathways that might be affected during COVID-19 disease
… , which are also useful as potential drug targets for certain reported drugs during COVID-19. …

COVID19 altered immune signalling pathways

S Sau, A Kumar - Science, 2021 - books.google.com
… of innate and adaptive immune signalling pathways after COVID-19 infection. Thus, in this …
the normal immune signalling pathways with COVID-19 altered immune signalling pathways, …

A comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID19 patients by phytotherapeutic melatonin and epigallocatechin …

V Chattree, K Singh, K Singh, A Goel… - Journal of food …, 2022 - Wiley Online Library
… In this review, we propose an alternative therapy for COVID-19 patients by supplementing
their diet with these nutraceuticals that perhaps by modulating sirtuin signaling pathways

[HTML][HTML] How COVID-19 induces cytokine storm with high mortality

S Hojyo, M Uchida, K Tanaka, R Hasebe… - Inflammation and …, 2020 - Springer
… activates ADAM17 and ADAM10 protease activity, and the resulting production of TNF-α,
sIL-6Rα, and EGF initiates the TNFR-NF-κB, IL-6R-STAT3, and EGF-NF-κB signaling pathways. …

[HTML][HTML] … signaling pathway is involved in the shedding of ACE2 catalytic ectodomain: new insights for clinical and therapeutic applications of ACE2 for COVID-19

A García-Escobar, S Vera-Vera, A Jurado-Román… - Biomolecules, 2022 - mdpi.com
… (SARS-CoV-1) and is 96% identical to a bat coronavirus [5]. … mortality in severe COVID-19
than in non-COVID-19 severe … been reported in severe COVID-19 and were associated with …