… IFN and JAK/STAT signaling. We propose that COVID-19 is a disease caused by a catastrophic
cascade of failures stemming from the SARS-CoV-2-mediated dysregulation of STATs. …

… COVID-19 patients, it drives our focus onto the signaling cascades of the JAK/STAT pathway…
receptor activation leads to phosphorylation of STATs that translocate into the nucleus to …

… of Transcription (STAT) proteins downstream of … in Coronavirus Disease 2019 (COVID-19).
In this report, cytokines found in the storm are discussed in relation to the JAK-STAT pathway …

… It has been reported COVID-19 keeps substantial nucleotide similarity and shares common
… pathways of SARS-Cov as a useful reference for a deepening understanding of COVID-19. …

… of vaccines and drugs against COVID-19. At present, the … elicited signaling pathways, we
introduced possible pathway-… pathways involved in the immunopathogenesis of COVID-19. …

… pathways involved in the inflammatory response. This review presents an overview of
SARS-CoV-2 and the COVID-19 … that have been reported in COVID-19 patients. The potential …

… The canonical JAK-STAT pathway is initiated upon high-affinity interaction between
extracellular signaling cytokines and their cognate receptors (Figure I). This interaction leads to the …

… threat and named it coronavirus disease-19 (COVID-19). Clinically, COVID-19 varied from
mild to … As the JAK/STAT pathway modulates important inflammatory and immunological …

… /STAT pathway is highly activated in acute inflammation, and the excessive activity of this
pathway in COVID-19 … Interestingly, the activation of this pathway in a positive feedback loop …

… the discovery of the JAK-STAT pathway 30 years ago brought a … COVID-19. Yet, it would
be misleading to not consider the challenges ahead—particularly since the JAK-STAT pathway …