… the discovery of the JAK-STAT pathway 30 years ago brought a … COVID-19. Yet, it would
be misleading to not consider the challenges ahead—particularly since the JAK-STAT pathway …

… IFN-induced STAT phosphorylation. The JAK/STAT pathway has been implicated in
carcinogenesis and viral pathogenesis, notably in pulmonary involvement from COVID-19. Progress …

… /STAT system already infected with the coronavirus, we observed that significant reduction
of size was achieved with baricitinib only. Coronavirus … related to JAK/STAT system. Several …

… of this pathway using JAK inhibitors (JAKinibs) is suggested as a promising approach in
patients with COVID-19 … that affect the JAK-STAT pathway in patients with COVID-19. Since the …

… Given the implication of the JAK-STAT pathway in the … been proposed to ameliorate COVID-19
symptomatology (reviewed … COVID-19 patients due to its capacity to block the JAK-STAT …

… in the immunopathological characteristics of COVID-19 and focus on CS including the …
related signal pathways. We believe that a comprehensive understanding of CS in COVID-19 will …

… with the inflammation of the JAK-STAT pathway. It was noted that endothelial cell … COVID-19
severity. TNF-α, IFN-γ, and IL-6 are important markers of cellular senescence and COVID-19 …

… that the activation of JAK/STAT pathway, mediated by IFNs, is … The defensive role of JAK/STAT
pathway is corroborated by … -encoded factors blocking this pathway, which are recognized …

… JAK/STAT pathway mediating Ang II functions is present in the cardiovascular system,
proximal tubular epithelial cells of kidney, astrocytes of brainstem, hepatocytes and mesangial …

… COVID-19 cases, which achieved rapid and sustained improvement in outcome with the use
of ruxolitinib, a JAK/STAT pathway … cytokine storm and JAK/STAT hyperactivation. To the …