Inflammation and JAK/STAT Signaling: New Clues for the Treatment of COVID-19

R Shirazinia, M Afshari, AA Golabchifar… - … Journal of Basic …, 2022 - ijbsm.zbmu.ac.ir
… inhibitor that, due to the inhibition of the JAK/STAT pathway, prevents the activity of various
kinds of cytokines that are involved in the pathogenesis of COVID-19. On the other hand, …

STAT1 and its crucial role in the control of viral infections

M Tolomeo, A Cavalli, A Cascio - International Journal of Molecular …, 2022 - mdpi.com
… These IFN/JAK/STAT signaling pathways are considered the canonical … through JAK-STAT
inhibition to limit cytokine storms have been proposed for the treatment of COVID-19. …

COVID-19 revisiting inflammatory pathways of arthritis

G Schett, B Manger, D Simon, R Caporali - Nature Reviews …, 2020 - nature.com
… Many viruses have developed strategies to counteract the effects of type I interferons, some
of which antagonize the JAK–STAT pathway 55 . Consequently, JAK blockade most likely …

Network meta‐analysis on the mechanisms underlying alcohol augmentation of COVID19 pathologies

W Huang, H Zhou, C Hodgkinson… - Alcoholism: Clinical …, 2021 - Wiley Online Library
… Our network meta-analysis identified key inflammatory pathways common to EtOH and
COVID-19 and provided potential mechanisms by which EtOH may impact the inflammatory …

IL-4/IL-13 remodeling pathway of COVID-19 lung injury

CB Vaz de Paula, MLV de Azevedo, S Nagashima… - Scientific Reports, 2020 - nature.com
COVID-19 once more caused by another respiratory virus, the SARS-CoV-2 new coronavirus
2 … Critical state COVID-19 patients require the use of mechanical ventilation 5 , and a study …

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

DY Chen, N Khan, BJ Close, RK Goel, B Blum… - Biorxiv, 2020 - biorxiv.org
… in patients with COVID-19. SARS-CoV-2, the virus behind the ongoing COVID-19 pandemic,
… time span of less than a year 1 (https://coronavirus.jhu.edu/map.html). The virus primarily …

[HTML][HTML] The role of type I interferons in the pathogenesis and treatment of COVID-19

G Schreiber - Frontiers in immunology, 2020 - frontiersin.org
… In addition, COVID-19 has been linked to cardiovascular sequelae, such as … of COVID-19
in relation to SARS. After membrane fusion, the virus enters through the endosomal pathway

Interleukin-6 blocking vs. JAK-STAT inhibition for prevention of lung injury in patients with COVID-19

J Meletiadis, S Tsiodras, P Tsirigotis - Infectious Diseases and Therapy, 2020 - Springer
… a common JAK-STAT signaling pathway, which can be inhibited by JAK-STAT inhibitors. …
and death without COVID-19 in patients with COVID-19 treated with immunosuppressive …

COVID-19: disease pathways and gene expression changes predict methylprednisolone can improve outcome in severe cases

S Draghici, TM Nguyen, LA Sonna, C Ziraldo… - …, 2021 - academic.oup.com
… the inflammatory pathways associated with the cytokine storm found in COVID-19 patients
… therapeutic approaches that, by targeting these pathways could effectible reduce the hyper-…

Use of JAK STAT Pathway Blocker To Treat COVID19 Patients-The Future of COVID19 Treatment

D Mukherjee, S Imam, KK Mukherjee - 2020 - papers.ssrn.com
… So with anti viral therapy, if we provide JAK-STAT pathway inhibitor like … COVID19 virus
works through this receptors. So JAK STAT pathway blocker are potent drug to treat COVID 19