M Tolomeo, A Cavalli, A Cascio - International Journal of Molecular …, 2022 - mdpi.com
… These IFN/JAK/STAT signaling pathways are considered the canonical … through JAK-STAT inhibition to limit cytokine storms have been proposed for the treatment of COVID-19. …
G Schett, B Manger, D Simon, R Caporali - Nature Reviews …, 2020 - nature.com
… Many viruses have developed strategies to counteract the effects of type I interferons, some of which antagonize the JAK–STATpathway 55 . Consequently, JAK blockade most likely …
W Huang, H Zhou, C Hodgkinson… - Alcoholism: Clinical …, 2021 - Wiley Online Library
… Our network meta-analysis identified key inflammatory pathways common to EtOH and COVID-19 and provided potential mechanisms by which EtOH may impact the inflammatory …
… COVID-19 once more caused by another respiratory virus, the SARS-CoV-2 new coronavirus 2 … Critical state COVID-19 patients require the use of mechanical ventilation 5 , and a study …
… in patients with COVID-19. SARS-CoV-2, the virus behind the ongoing COVID-19 pandemic, … time span of less than a year 1 (https://coronavirus.jhu.edu/map.html). The virus primarily …
G Schreiber - Frontiers in immunology, 2020 - frontiersin.org
… In addition, COVID-19 has been linked to cardiovascular sequelae, such as … of COVID-19 in relation to SARS. After membrane fusion, the virus enters through the endosomal pathway …
J Meletiadis, S Tsiodras, P Tsirigotis - Infectious Diseases and Therapy, 2020 - Springer
… a common JAK-STAT signaling pathway, which can be inhibited by JAK-STAT inhibitors. … and death without COVID-19 in patients with COVID-19 treated with immunosuppressive …
… the inflammatory pathways associated with the cytokine storm found in COVID-19 patients … therapeutic approaches that, by targeting these pathways could effectible reduce the hyper-…
D Mukherjee, S Imam, KK Mukherjee - 2020 - papers.ssrn.com
… So with anti viral therapy, if we provide JAK-STATpathway inhibitor like … COVID19 virus works through this receptors. So JAK STATpathway blocker are potent drug to treat COVID19…