… and bioactivity of luteolin and analyze the targets and signaling pathways of luteolin
against COVID-19/asthma comorbidity. The flow diagram of our research is shown in Figure 1. …

… of Coronavirus Disease-2019 (COVID-19) has … COVID-19 is caused by a novel virus
coronavirus strain, SARS-CoV-2, an enveloped, positive-sense, single-stranded RNA, β-coronavirus …

… could be the targets of interest for investigations to manage COVID-19. … Given the scarcity
of treatment to combat COVID-19, the present study focused on identifying JAK-STAT pathway …

… While IRFs lead to secretion of type I interferons (IFNs), which exert their function by signalling
through the JAK-STAT pathway and the subsequent IFN stimulated genes (ISG) synthesis, …

… The Jak-Stat pathway is essential for the innate and adaptive antiviral response by the B,
T, … As far as the results are concerned, the Jak-Stat pathway is activated with the strongest …

… terms and pathway analysis and found some common associations among COVID-19,
ARDS and … drugs obtained in this study may contribute to the effective treatment of COVID-19. …

… coronavirus 2 (SARS-CoV-2) was identified as the causative agent of coronavirus infectious
disease 2019 (COVID-19) … Health Organization declared the COVID-19 outbreak a global …

… remain to be identified, but it is crucial that we establish the pathways involved in the
different stages of the inflammatory response to SARS-CoV-2 and determine the contribution of …

… Moreover, IFN-α/β binding with IFNR dimer receptors activates the JAK-STAT pathway,
which renders the production and subsequent nuclear translocation of STAT1, STAT2 and IRF9 …

… Tests are expected to be of value in the COVID-19 crisis. In … In the current study JAK-STAT
pathway analysis was … For this reason, development of qPCR-based JAK-STAT pathway tests …