[HTML][HTML] A potential treatment of COVID-19 with TGF-β blockade

WJ Chen - International Journal of Biological Sciences, 2020 - ncbi.nlm.nih.gov
… Based on the clinical and laboratory features and lung pathological manifestations of
COVID-19 … for the severe COVID-19 through blockade of transforming growth factor-beta (TGF-β). …

Possible role of matrix metalloproteinases and TGF-β in COVID-19 severity and sequelae

G Ramírez-Martínez, LA Jiménez-Álvarez… - Journal of interferon & …, 2022 - liebertpub.com
transforming growth factor-beta (TGF-β) in immune responses of the lungs. Furthermore, we
discuss their possible implications in severe COVID-19 … of convalescent COVID-19 patients. …

[HTML][HTML] COVID-19: immunohistochemical analysis of TGF-β signaling pathways in pulmonary fibrosis

CB Vaz de Paula, S Nagashima, V Liberalesso… - International journal of …, 2021 - mdpi.com
… of TGF-β pathways in the … TGF-β inhibitors in those patients recovered from COVID-19
to mitigate a possible development of pulmonary fibrosis and its consequences for post-COVID-19

[HTML][HTML] Microvascular significance of TGF-β axis activation in COVID-19

LM Arguinchona, C Zagona-Prizio, ME Joyce… - Frontiers in …, 2023 - frontiersin.org
… on the microvasculature in COVID-19. In addition, we explore the potential role of existing
TGF-β inhibitors for the prevention and treatment of COVID-19 associated microvascular …

[HTML][HTML] Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

…, RL Chua, T Aschman, C Meisel, J Radke, B Sawitzki… - Nature, 2021 - nature.com
… In severe COVID-19, serum levels of TGFβ peak during the first two … in a TGFβ-dependent
manner. Our data reveal that an untimely production of TGFβ is a hallmark of severe COVID-19

Repurposing of histone deacetylase inhibitors: A promising strategy to combat pulmonary fibrosis promoted by TGF-β signalling in COVID-19 survivors

K Sivashanmugam, M Kandasamy, R Subbiah… - Life sciences, 2021 - Elsevier
Coronavirus disease 2019 (COVID-19) has rapidly spread … coronavirus (SARS-CoV),
Influenza A virus subtype H1N1 and most recently Middle East respiratory syndrome coronavirus (…

[HTML][HTML] SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

M Ferreira-Gomes, A Kruglov, P Durek… - Nature …, 2021 - nature.com
… with additional TGF-β (Fig. 3a). In summary, severely affected COVID-19 patients show a …
, which initially is controlled by IFNs, IL-2, and TGF-β, and later on predominantly by TGF-β. …

Cytokine profile and disease severity in patients with COVID-19

A Ghazavi, A Ganji, N Keshavarzian, S Rabiemajd… - Cytokine, 2021 - Elsevier
Transforming growth factor β (TGF-β), a pleiotropic cytokine with potent regulatory and
inflammatory activity, which is important for balancing the immune response [22], was increased …

[HTML][HTML] NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity

J Barros-Martins, R Förster, B Bošnjak - Signal Transduction and …, 2022 - nature.com
COVID-19. Nevertheless, implications of this important study could include the monitoring
of plasma TGF-β levels in COVID-19 … use of TGF-β blockers in the treatment of COVID-19. …

[PDF][PDF] Post-COVID-19 pulmonary fibrosis

A Mohammadi, I Balan, S Yadav, WF Matos… - Cureus, 2022 - cureus.com
… Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions …
severe COVID-19 infection. Rise in inflammatory markers like transforming growth factor β (TGF-β)…