Neutrophil extracellular traps and by-products play a key role in COVID-19: pathogenesis, risk factors, and therapy

AR Thierry, B Roch - Journal of clinical medicine, 2020 - mdpi.com
… We include an overview of NET formation, function and pathogenic dysregulation, as well …
Because of the complexity of both COVID-19 and of NET formation, which involve a great …

Significance of NETs formation in COVID-19

K Janiuk, E Jabłońska, M Garley - Cells, 2021 - mdpi.com
traps (NETs) playing a significant role in the mechanism of combating pathogens, in the
pathogenesis of COVID-19. … on the severe course of COVID-19 in patients with concurrent …

… peripheral blood neutrophil activation phenotypes and neutrophil extracellular trap formation in critically ill coronavirus disease 2019 (COVID-19) patients: a case …

JA Masso-Silva, A Moshensky, MTY Lam… - Clinical Infectious …, 2022 - academic.oup.com
… histone H3, and DNA are seen in COVID-19 patient sera [18, 19]. While treatment of naive
COVID-19 patients stimulated NETosis [19] and NETs are seen in lung tissue of COVID-19

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

EA Middleton, XY He, F Denorme… - Blood, The Journal …, 2020 - ashpublications.org
… In this study, we provide clinical evidence that increased NET formation correlates with
COVID-19–related ARDS and is a potential biomarker for disease severity. We also demonstrate …

Neutrophil extracellular trap formation potential correlates with lung disease severity in COVID-19 patients

N Kinnare, JS Hook, PA Patel, NL Monson… - Inflammation, 2022 - Springer
… Treatment options for COVID-19 are limited and primarily … NET formation in the lungs of
severely ill COVID-19 patients, … We hypothesized that the NET formation potential of circulating …

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

BJ Barnes, JM Adrover, A Baxter-Stoltzfus… - Journal of Experimental …, 2020 - rupress.org
… (NETs)—may contribute to organ damage and mortality in COVID-19. We show lung …
succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary …

On the origin of neutrophil extracellular traps in COVID-19

M Pastorek, M Dúbrava, P Celec - Frontiers in Immunology, 2022 - frontiersin.org
… has been shown and proved, the causes of NETs formation are unclear. The aim of … formation
in severe COVID-19 and to discuss potential treatment options targeting NETs formation of …

Vascular occlusion by neutrophil extracellular traps in COVID-19

M Leppkes, J Knopf, E Naschberger, A Lindemann… - …, 2020 - thelancet.com
… Here, we show that severe COVID-19 is characterized by a highly pronounced formation
of neutrophil extracellular traps (NETs) inside the micro-vessels. Intravascular aggregation of …

Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality

HM Al-Kuraishy, AI Al-Gareeb, HA Al-Hussaniy… - International …, 2022 - Elsevier
… Different studies proposed that NETs formation in Covid-19 might be the potential cause of
venous and arterial thrombo-embolism due to vasculitis and immune-mediated mechanism […

The balance of neutrophil extracellular trap formation and nuclease degradation: an unknown role of bacterial coinfections in COVID-19 patients?

N de Buhr, M von Köckritz-Blickwede - MBio, 2021 - Am Soc Microbiol
… for severe COVID-19 to degrade NETs. Based on the described NET formation in COVID-19
alfa (Pulmozyme) for the treatment of severe COVID-19 ARDS (44). Interestingly, local …