COVID-19: drug targets and potential treatments

C Gil, T Ginex, I Maestro, V Nozal… - Journal of medicinal …, 2020 - ACS Publications
… this coronavirus, COVID-19. In this paper, we will focus on the main virus-based and host-based
targets … In principle, all CoV enzymes and proteins involved in viral replication and the …

Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
… pathogenesis of COVID-19. Both the virus and host factors are potential targets for antiviral
… therapeutic strategies of COVID-19 have been classified into “target virus” and “target host” …

Precision therapeutic targets for COVID-19

ZA Krumm, GM Lloyd, CP Francis, LH Nasif… - Virology journal, 2021 - Springer
targets for antiviral activity: spike (S) protein, the main viral protease (M Pro ), and RNA-dependent
RNA polymerase (RdRp). Aspects of these targets … -CoV-2 targets. Listed are the main …

Viral targets for vaccines against COVID-19

L Dai, GF Gao - Nature Reviews Immunology, 2021 - nature.com
… Vaccines are urgently needed to control the coronavirus disease 2019 (COVID-19) …
viral elements are used in COVID-19 vaccine candidates, why they might act as good targets

The role of lipid metabolism in COVID-19 virus infection and as a drug target

M Abu-Farha, TA Thanaraj, MG Qaddoumi… - International journal of …, 2020 - mdpi.com
Viral entry is dependent on the attachment and fusion of viral membrane with plasma … this
review and the ongoing COVID-19 pandemic is the role of lipid rafts in viral entry into the host …

Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
COVID-19 and other infectious diseases with regard to drug repurposing strategies, pan-coronavirus
drug targets, in … for these viral targets at various stages of the viral life cycle (Fig. 2). …

Drug targets for COVID-19 therapeutics: Ongoing global efforts

A Saxena - Journal of biosciences, 2020 - Springer
… The causative virus of COVID-19 pandemic, SARS-CoV-2 virus is a part Betacoronavirus
subfamily and is believed to have crossed the species barrier to infect humans due to zoonotic …

COVID19 metabolism: Mechanisms and therapeutic targets

T Wang, Y Cao, H Zhang, Z Wang, CH Man… - MedComm, 2022 - Wiley Online Library
… Although the exact role of liver injury in COVID-19 development remained under discussion,
67 viral infection-induced elevation of aspartate aminotransferase (AST) and alanine …

[HTML][HTML] Roles of existing drug and drug targets for COVID-19 management

AG Ayele, EF Enyew, ZD Kifle - Metabolism Open, 2021 - Elsevier
… Thus, this review aimed to focus on the most promising therapeutic targets being repurposed
against COVID-19 and viral elements that are used in COVID-19 vaccine candidates. …

A review on novel drug targets and future directions for COVID-19 treatment

YT Wondmkun, OA Mohammed - Biologics: Targets and Therapy, 2020 - Taylor & Francis
… Accordingly, numerous drug targets are identified by scientists. Among … targets for COVID-19,
and highlights antiviral strategies which depend on molecular interactions between viral