… called cpc-3, showed 35% positional identity over almost the entire sequence with GCN2 of
yeast… functions as a translational activator of cpc-1, analogous to the function of yeast GCN2. …

… in fission yeast … Gcn2 autophosphorylation, which is essential for Gcn2 function. These
results indicate that S. pombe Cpc2 facilitates the GAAC response through the regulation of Gcn2 …

… set, three genes known or likely to be involved in the translational regulation of cpc-1 were
identified, including cpc-3, a GCN2 … patterns in these three diverse fungal species under a …

… Mutations in GCN2 or GCN4 result in yeast strains unable to … the yeast cpc2 deletion, the
cpc-2 gene complements the yeast cpc2Δ mutation, suggesting that N. crassa cpc-2 and yeast …

… CPC-3, the homolog of yeast and mammalian GCN2. Binding of uncharged tRNA to GCN2,
… domain is conserved in all GCN2 homologs [45], we speculated that CPC-3 in N. crassa is …

… In this study, we discovered that the disruption of the GCN2 (CPC- 3) signaling pathway
abolished … The yeast GCN4 was previously shown to recruit the histone acetyltransferase GCN5 …

… Thus, like yeast GCN2 and N. crassa CPC3, MGCN2 possesses the sequences AAGGRYD
(… We also wished to determine whether MGCN2 kinase, like yeast GCN2, had the ability to be …

… yeast, amino acid starvation leads to the intracellular accumulation of uncharged tRNAs, which
interact with the regulatory histidyl-tRNA synthetase-like domain of Gcn2… of the cpc-1 and …

… GCN2 has been well studied for its role in amino acid starvation stress responses, so we can
use studies of GCN2 to inform our understanding of CPC-3 … of CPC-3 in yeast (GCN2) have …

… crassa cells with 3-aminotriazole (3-AT), which induces … abundant in the coding region of
cpc-1 and relatively less abundant … of cpc-1 by uORFs and regulatory roles of conserved Gcn2 …