… , now exceed the gene-editing functionality of WT Cas9. Here, we will present a brief history
of gene-editing tools and describe the wide range of CRISPR-based genome-targeting tools…

… Genome editing took a dramatic turn with the development of the clustered regularly interspaced
short palindromic repeats (CRISPR)-CRISPR-… genome editing technology, and CRISPR …

… To the Editor: Recent progress in genome editing technologies, in particular the CRISPR-…
to investigate the biological functions of genomic sequences by targeted mutagenesis 1,2,3,4 . …

… CRISPR/Cas pathways that operate in bacteria and archaea, and briefly introduce the
genome-editing … greater depth and detail throughout the rest of this issue of Human Gene Therapy. …

… of Cas9 for genome editing, regulation, and imaging, discuss other possible applications
and some technical considerations, and highlight the many advantages that CRISPR/Cas9 …

… As we transition into the next decade of CRISPR genome editing, several key challenges
demand innovative solutions. Two of these are editing accuracy (ie, specificity for the target site…

… to be addressed for this emerging genome editing platform. From bacterial CRISPR-Cas
immune system to engineered RNA-guided nucleases CRISPR systems are adaptable immune …

… the gene editing experiment. However, there are no computational tools for genome editing
… We present a platform to assess the quality of a genome editing experiment only with three …

… CRISPR/Cas9 gene editing has also been applied in immunology-focused applications such
as the targeting of CC chemokine receptor type 5, the programmed death 1 gene… , CRISPR/…

… Here, we describe a member of the type-V CRISPR–Cas12b family from Bacillus hisashii
that is suitable for genome editing in human cells. Following our work, we also identified a …