Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

L Vanderbeke, P Van Mol, Y Van Herck… - Nature …, 2021 - nature.com
… of these cytokines to COVID-19 is not … for critically ill COVID-19 patients, we have performed
the first direct comparison between the plasma cytokine profiles in COVID-19 critical clinical …

[HTML][HTML] A score combining early detection of cytokines accurately predicts COVID-19 severity and intensive care unit transfer

C Nagant, F Ponthieux, J Smet, N Dauby… - International Journal of …, 2020 - Elsevier
cytokine profile in patients as it relates to Coronavirus Disease 2019 (COVID-19) severity,
and to establish a predictive cytokine … and anticipate severe or critical evolution of COVID-19. …

Immunological and inflammatory profiles during acute and convalescent phases of severe/critically ill COVID-19 patients

Q Chen, B Yu, Y Yang, J Huang, Y Liang, J Zhou… - International …, 2021 - Elsevier
cytokine-mediated inflammatory response, dysregulation of CD8 T cells and NK cells,
and deficiency of host mDCs and pDCs occur in severe and critically ill patients with COVID-19. …

COVID-19: immunopathogenesis and Immunotherapeutics

L Yang, S Liu, J Liu, Z Zhang, X Wan… - Signal transduction and …, 2020 - nature.com
… that cytokine levels, including IL2, IL-4, IL-6, IL-10, TNF-α and IFN-γ, are elevated in severe
and critical COVID-19 cases, particularly IL-6 … The specific immune profiles of COVID-19 can …

[HTML][HTML] The COVID-19 cytokine storm; what we know so far

D Ragab, H Salah Eldin, M Taeimah… - Frontiers in …, 2020 - frontiersin.org
… analyzing cytokine profiles from COVID-19 patients suggested that the cytokine storm …
treatment of 21 patients with severe and critical COVID-19. Clinical data showed that the symptoms…

Characterisation of the pro-inflammatory cytokine signature in severe COVID-19

HC Hawerkamp, AH Dyer, ND Patil… - Frontiers in …, 2023 - frontiersin.org
… for moderate cytokine inflammation in COVID-19 at consistent … for IL-6 – the most widely
studied cytokine in acute COVID-19 - … a distinct cytokine profile and severe/critical COVID-19. …

Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position paper

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
… the cytokine storm and its implications in COVID-19 settings … paper provides critical insights
on cytokine storm from both a … -2 virus, revealed a cytokine profile similar to that of secondary …

Clinical significance of measuring serum cytokine levels as inflammatory biomarkers in adult and pediatric COVID-19 cases: A review

BM Liu, TB Martins, LK Peterson, HR Hill - Cytokine, 2021 - Elsevier
… serum SARS-CoV-2 viral load in critically ill COVID-19 patients, suggesting a potential to
utilize … biosignature depicted by multiplex cytokine profiling was studied to predict COVID-19

Dynamic changes in lymphocyte subsets and parallel cytokine levels in patients with severe and critical COVID-19

Y Liu, W Tan, H Chen, Y Zhu, L Wan, K Jiang… - BMC infectious …, 2021 - Springer
… Dynamic changes of inflammatory cytokines in severe and critical COVID-19. Serum levels
of IL-2 (a), IL-4 (b), Ln(IL-6) (c), IL-10 (d), TNF-α(e) and IFN-γ (f) were analyzed at different …

Comprehensive antibody and cytokine profiling in hospitalized COVID-19 patients in relation to clinical outcomes in a large Belgian cohort

P Ruytinx, P Vandormael, J Fraussen, Z Pieters… - Scientific Reports, 2023 - nature.com
… Higher serum IgM levels have been correlated with a higher mortality rate in severe/critical
COVID-19 patients 11 , whereas other studies showed that lower antibody levels are linked …