[HTML][HTML] Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna

C Hinderer, P Bell, CH Vite, JP Louboutin… - … Therapy Methods & …, 2014 - cell.com
… We treated six cynomolgus macaques with an intrathecal injection of a single-stranded
AAV9 vector expressing GFP from either the cytomegalovirus (CMV) or chicken beta-actin (CB) …

[HTML][HTML] In utero transfer of adeno-associated viral vectors produces long-term factor IX levels in a cynomolgus macaque model

CNZ Mattar, I Gil-Farina, C Rosales, N Johana… - Molecular Therapy, 2017 - cell.com
… Here, we report long-term transgene expression over more than 6 years without toxicity
following a single intrauterine gene transfer (IUGT) at 0.9G using recombinant adeno-associated …

[HTML][HTML] In Vivo Safety and Persistence of Endoribonuclease Gene-Transduced CD4+ T Cells in Cynomolgus Macaques for HIV-1 Gene Therapy Model

H Chono, N Saito, H Tsuda, H Shibata, N Ageyama… - PLoS …, 2011 - journals.plos.org
… of MazF-transduced cynomolgus macaque CD4+ T cells … Autologous T cell transfer in HIV
patients began in the mid 1990's, and … The majority of these clinical trials used gene transfer by …

Optimized adeno-associated viral-mediated human factor VIII gene therapy in cynomolgus macaques

JA Greig, JML Nordin, JW White, Q Wang… - Human Gene …, 2018 - liebertpub.com
… developed, which varied between 8 and 20 weeks following gene transfer. The effect of
immunosuppression in these cynomolgus macaques fell into three categories: (1) a decrease in …

[HTML][HTML] Biology of AAV serotype vectors in liver-directed gene transfer to nonhuman primates

G Gao, Y Lu, R Calcedo, RL Grant, P Bell, L Wang… - Molecular Therapy, 2006 - cell.com
… This study evaluates the biology of AAV-mediated gene transfer to liver in … macaques.
Experiments were performed with bCG in rhesus macaques and Epo in cynomolgus macaques. …

[HTML][HTML] MHC-identical and transgenic cynomolgus macaques for preclinical studies

H Ishigaki, T Shiina, K Ogasawara - Inflammation and Regeneration, 2018 - Springer
… Second, to obtain disease models of cynomolgus macaques for studies on regenerative … of
genetic technology to modify cynomolgus macaques: transgenic technology and gene editing …

[HTML][HTML] Lentiviral vector gene transfer into fetal rhesus monkeys (Macaca mulatta): lung-targeting approaches

AF Tarantal, CI Lee, JE Ekert, R McDonald, DB Kohn… - Molecular Therapy, 2001 - cell.com
gene transfer in fetal monkeys using an intrapulmonary approach; (2) less transduction of
non-pulmonary tissues with gene transfer at … in the cynomolgus and rhesus macaque (Macaca …

[HTML][HTML] TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys

H Liu, Y Chen, Y Niu, K Zhang, Y Kang, W Ge, X Liu… - Cell stem cell, 2014 - cell.com
… Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage … cynomolgus
macaques from one-cell embryos. MECP2 is an X-linked, monoallelically expressed gene

[HTML][HTML] Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene …

AF Tarantal, RJ McDonald, DF Jimenez, CCI Lee… - Molecular Therapy, 2005 - cell.com
… Prenatal growth in the cynomolgus and rhesus macaque (Macaca fascicularis and Macaca
… Evaluation of the bioeffects of prenatal ultrasound exposure in the cynomolgus macaque (…

[HTML][HTML] Prednisolone and rapamycin reduce the plasma cell gene signature and may improve AAV gene therapy in cynomolgus macaques

A Kistner, JA Chichester, L Wang, R Calcedo, JA Greig… - Gene Therapy, 2024 - nature.com
… therapy is a result of prophylactic IS or natural seroconversion, and the potential impact
on gene transfer, is warranted in future studies. In study 1 of this report, NHPs treated with …