… (TLRs) mainly TLR3, TLR7, and TLR9 have been related to the COVID-19 severe …
proinflammatory cytokines, cytokine receptors, and TLRs predispose patients to COVID-19 disease …

… receptor inhibits JAK2 and STAT5 activation. The binding of SOCS3 to other cytokine receptors
such as Tyr757 of gp130 receptor, Tyr985 of the leptin receptor, Tyr800 of IL-12 receptor …

… In summary, during COVID-19 disease, one of … IL-6 receptor using tocilizumab to prevent
serious complications from SARS-CoV-2 (Pelaia et al. 2021). The administration of IL-6 receptor …

… Cytokine dysregulation is the proposed mechanism for Coronavirus disease 2019 (COVID-19)…
also suggested the role of cytokine storm in the severity of COVID-19 disease [14]. Higher …

… coronavirus infectious disease 2019 (COVID-19) that is spreading at the global scale is caused
by a severe acute respiratory syndrome coronavirus … family, genus beta-coronavirus [1]. …

… the role of systemic vasculitis and cytokine mediated coagulation disorders as the principal
actors of multi organ failure in patients with severe COVID-19 complications. The following …

… COVID-19 patients. Tocilizumab is an IL-6 receptor (IL-6R) blocker that can effectively block
the … that it should be used in critically ill COVID-19 patients with significantly elevated IL-6. …

… level of IL-6 may predict the progression of COVID-19 disease. … IL-6 first binds to its receptor
(IL-6R), and then the IL-6/sIL-6R … pathway, IL-6 binds to the membrane-bound IL-6 receptor (…

… with severe COVID 19 disease reported higher levels of IL-2R, IL-6, … cytokine, the IL-6
receptor is a potential target to reduce acute inflammatory responses. The human anti-IL-6 receptor …

… be the main cause of disease severity and death in patients with COVID-19, 5 and is related
… but can also bind to the membrane-bound IL-6 receptor (mIL-6R) through gp130 to act in …