The deregulated immune reaction and cytokines release storm (CRS) in COVID-19 disease

R Pasrija, M Naime - International Immunopharmacology, 2021 - Elsevier
… Although cytokines are messenger molecules of the immune system, … response results in
the precarious pathogenesis of COVID-19; thus, a complete estimation of the immune response

Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
… aspect in the novel Coronavirus disease 2019 (COVID-19). For … mitigate the cytokine storm
in the treatment of COVID-19 patients… of cytokine storms, analyzing its role in COVID-19 and …

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
… -purposed anti-viral medicines, it remains of utmost importance to use the knowledge at our
disposal to treat those patients most at risk of dying from Covid-19-induced cytokine storms. …

Imaging mass cytometric analysis of postmortem tissues reveals dysregulated immune cell and cytokine responses in multiple organs of COVID-19 patients

C Wang, J Xu, S Wang, S Pan, J Zhang, Y Han… - Frontiers in …, 2020 - frontiersin.org
… However, most of the information regarding the dysregulation of immune cells and cytokines
… to profile COVID-19-associated immune cell and pro-inflammatory cytokine responses in …

The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

M Blot, JB Bour, JP Quenot, A Bourredjem… - Journal of translational …, 2020 - Springer
… We identified a unique cytokine response, with higher plasma GM-CSF and CXCL10 in
COVID-19 patients that were … These cytokines could represent the dysregulated immune …

… cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to counter cytokine storm

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
… a normal and dysfunctional cytokines response as some cytokines are essential to generate
an effective immune response to clear intracellular infections such as viral infection [19]. …

The cytokine profiles and immune response are increased in COVID19 patients with type 2 diabetes mellitus

M Zheng, X Wang, H Guo, Y Fan, Z Song… - Journal of diabetes …, 2021 - Wiley Online Library
… cell, CD4 + /CD8 + ratio percentage, IL-6, and IL-10 between the NDM group and … COVID-19
patients with elevated glucose levels have promoted cytokine profiles and immune response

[PDF][PDF] Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury

Y Liu, C Zhang, F Huang, Y Yang, F Wang… - National Science …, 2020 - academic.oup.com
… of cytokine responses may play … cytokines/chemokines in blood plasma in COVID-19-S
patients versus healthy individuals, suggesting the occurrence of hypercytokinemia in COVID-19-…

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

DE Leisman, L Ronner, R Pinotti, MD Taylor… - The Lancet …, 2020 - thelancet.com
… to COVID-19 (460 pg/mL, 216·3–978·7 pg/mL; p<0·0001). Our findings question the role of a
cytokine storm in COVID-19-… features of COVID-19 and the potential role of anti-cytokine and …

Cytokine storm in COVID-19: the current evidence and treatment strategies

Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
… identify the cytokine storm. In this review, we referred COVID-19 associated cytokine storm as
… patients who are severely ill along with a high concentration of pro-inflammatory cytokines. …