Targeting the “cytokine storm” for therapeutic benefit

RV D'Elia, K Harrison, PC Oyston… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
responses may improve outcome. We review some of the current candidates for treatment of
cytokine storms which … therapeutic candidates that target the pathogen rather than the host …

[HTML][HTML] The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine stormstherapeutic

Weathering the cytokine storm in COVID-19: therapeutic implications

G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
cytokine release in response to viral infection, a condition known as cytokine release
syndrome (CRS) or cytokine storm… timed anti-inflammatory therapeutic strategies could improve …

[HTML][HTML] Immunopathogenesis and treatment of cytokine storm in COVID-19

JS Kim, JY Lee, JW Yang, KH Lee, M Effenberger… - Theranostics, 2021 - ncbi.nlm.nih.gov
… characteristics of cytokine storm are similar, … and treatment response in individual forms of
cytokine storm can differ. Thus, it is important to find the key cytokine in various cytokine storms

[HTML][HTML] Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy

Y Jiang, L Rubin, T Peng, L Liu, X Xing… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
… Therefore, suppression of the cytokine storm is critical for reducing … of cytokine storm and
tissue damage induced by SARS-CoV-2 infection and reviews diagnosis and current therapies

[HTML][HTML] Dynamics of a cytokine storm

HH Yiu, AL Graham, RF Stengel - 2012 - journals.plos.org
Cytokines … to cytokine production are destabilized, a "cytokine storm" (or hypercytokinemia)
can result, producing unbridled inflammation within tissues and key organs. Cytokine storms

[HTML][HTML] Immunoregulatory therapy strategies that target cytokine storms in patients with COVID‑19

X Wang, Z He, X Zhao - Experimental and Therapeutic …, 2021 - spandidos-publications.com
… Immunoregulatory therapies target the cytokine storms … Although there are as yet no specific
treatments for the cytokine storms … discusses these treatment strategies for cytokine storms in …

[HTML][HTML] Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19

JT Sims, V Krishnan, CY Chang, SM Engle… - Journal of Allergy and …, 2021 - Elsevier
… substantial amounts of proinflammatory cytokines, which may … cytokine storm, along with
changes in vascular endothelial markers that may better inform us of the therapeutic response, …

[HTML][HTML] Cytokine storm in COVID-19: the current evidence and treatment strategies

Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
… identify the cytokine storm. In this review, we referred COVID-19 associated cytokine storm as
… patients who are severely ill along with a high concentration of pro-inflammatory cytokines. …

Review on therapeutic targets for COVID-19: insights from cytokine storm

ML de Mélo Silva Júnior, LMA de Souza… - Postgraduate …, 2021 - academic.oup.com
response, which has been called ‘cytokine storm’. … (cytokine storm) and tissue damage.
Some drugs have been studied as therapeutic targets (block to viral entry or to cytokine storm) …