The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

D Darif, I Hammi, A Kihel, IEI Saik, F Guessous… - … pathogenesis, 2021 - Elsevier
… effective therapeutic approaches in COVID-19. Here, we review the current understanding
of pro-inflammatory cytokines associated with COVID-19 outcome and their relationship with …

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

C Wang, J Xie, L Zhao, X Fei, H Zhang, Y Tan, X Nie… - …, 2020 - thelancet.com
coronavirus 2 (SARS-CoV-2) by postmortem biopsies. Another report described the early
phase of the lung pathology of COVID-19 … of lungs in patients of COVID-19 with mild symptoms. …

Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications

C Pelaia, C Tinello, A Vatrella… - Therapeutic …, 2020 - journals.sagepub.com
… , in critically ill COVID-19 patients, cytokine storm and cytokine dysregulation lead to
remarkable pathological consequences. Indeed, the cytokine storm elicits immunological changes …

Cytokine storm: the primary determinant for the pathophysiological evolution of COVID-19 deterioration

R Chen, Z Lan, J Ye, L Pang, Y Liu, W Wu… - Frontiers in …, 2021 - frontiersin.org
cytokine storms promote the deterioration of COVID-19. Here, we outline the pathophysiological
processes through which cytokine storms … , as well as the pathophysiology of immune …

[HTML][HTML] Aveolar macrophage activation and cytokine storm in the pathogenesis of severe COVID-19

C Wang, J Xie, L Zhao, X Fei, H Zhang, Y Tan, L Zhou… - 2020 - europepmc.org
… These findings shed new insights into the pathogenesis of COVID-19 and justify the use of
… drivers of “cytokine storm syndrome” in COVID19. Additionally, an elevated serum IL6 was …

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
… Then, a cytokine storm can induce edematous, ARDS, … till now why cytokine storm induces
in only COVID-19 elderly patients… between cytokine storm in elderly patients of COVID-19 and “…

Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position paper

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
… Understanding the pathogenesis of cytokine storm will help unravel not only risk factors for
the condition but also therapeutic strategies to modulate the immune response and deliver …

Overview of the pathogenesis of COVID19

C Li, Q He, H Qian, J Liu - … and Therapeutic Medicine, 2021 - spandidos-publications.com
… and the secretion of IL-1β in macrophages, suggesting that PAMP-PRR signaling in
macrophages may result in the release of proinflammatory cytokines in COVID-19(15). …

A glimpse into the eye of the COVID-19 cytokine storm

K Kuppalli, AL Rasmussen - EBioMedicine, 2020 - thelancet.com
… The pathogenesis of pandemic coronavirus disease-2019 (… with cytokine storms and
COVID-19 severity, further data from other cohorts of COVID-19 patients must be obtained. …

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …

J Wang, M Jiang, X Chen… - Journal of Leucocyte …, 2020 - academic.oup.com
… curtail the cytokine storm in coronavirus 2019 (COVID-19) … and cytokine data associated with
COVID-19 disease in 3939 … studies aimed at blocking proinflammatory cytokines; transfer of …