Risk factors associated with the clinical outcomes of COVID-19 and its variants in the context of cytokine storm and therapeutics/vaccine development challenges

J Hanna, P Tipparaju, T Mulherkar, E Lin, V Mischley… - Vaccines, 2021 - mdpi.com
… factors that may contribute to disease severity and predict COVID-19 outcomes. In doing so,
… and cytokine storm (frequently seen in COVID-19 patients) with a focus on the IL-6 pathway. …

[PDF][PDF] Cytokine storm syndrome in COVID-19: diagnosis and management strategies

S Maggo, P Dhull, AP Dubey, D Brashier… - Int J Health Sci …, 2020 - researchgate.net
… “cytokine storm syndrome”. It is prudent to diagnose cytokine storm early in the course of
disease … The outcome of infection depends chiefly on host immune system response. The initial …

The looming storm: blood and cytokines in COVID-19

S Kaur, R Bansal, S Kollimuttathuillam, AM Gowda… - Blood reviews, 2021 - Elsevier
… are emerging as important prognostic marker for worse outcome of COVID-19. Among …
including cytokine storm, hypercoagulable state and some rare presentations of this disease

Cytokine storm associated coagulation complications in COVID-19 patients: Pathogenesis and Management

SR Savla, KS Prabhavalkar, LK Bhatt - Expert review of anti …, 2021 - Taylor & Francis
… (cytokine storm). Recent studies propose an active role of coagulation disorders in disease
… , microvascular thrombosis, VTE and related outcomes like DIC and multi-organ failure. …

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue

X Yongzhi - Emerging microbes & infections, 2021 - Taylor & Francis
… , cytokine release syndrome (CRS), and cytokine storm (CS). Hematologic malignancies and
autoimmune diseases that … evolution of CSS classifications, cytokines associated with CSS, …

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
… levels were not subsequently ascertained in this study, the pretreatment IL-6 concentration
aligns with severe disease cutoffs in those studies mentioned earlier. Of immense importance …

Can tocilizumab calm the cytokine storm of COVID-19?

GS Schulert - The Lancet Rheumatology, 2020 - thelancet.com
disease had clinical and laboratory features of hyperinflammation and cytokine storm, including
elevated levels of interleukin-6 (IL-6… have different clinical outcomes using PBMCs would …

Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis

S Ramasamy, S Subbian - Clinical microbiology reviews, 2021 - Am Soc Microbiol
… SARS-CoV-2 infection in people results in a range of clinical outcomes, from asymptomatic
to mild, moderate, or severe disease with symptoms that include high fever, cough, fatigue, …

Shelter from the cytokine storm: Healthy living is a vital preventative strategy in the COVID-19 era

R Arena, S Bond, IR Calvo, L Lebowicz… - … Diseases, 2022 - Elsevier
cytokine storm is a phenomenon that has been posited as a pathophysiologic response to
COVID-19 infection that leads to poor outcomes. … vulnerability to the cytokine storm as well as …

Forecasting the cytokine storm following systemic interleukin (IL)-2 administration

MC Panelli, R White, M Foster, B Martin… - Journal of translational …, 2004 - Springer
… High serum levels of MMP 2 and 9 have been reported in inflammatory diseases of the …
of production of cytokines during IL-2 therapy that may be of relevance to clinical outcome and …