Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position paper

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
… with and without the cytokine storm to understand the specific immunopathological
mechanisms and biomarkers for severe disease. After cytokine storm resolves, an immunologic …

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

R Channappanavar, S Perlman - Seminars in immunopathology, 2017 - Springer
… and elevated pro-inflammatory cytokine/chemokine responses … for virus-induced
immunopathological events in causing fatal … may cause lung immunopathology leading to …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokines are intricately linked to cell death mechanisms in mammals and are involved in
a positive feedback loop, whereby cytokineCytokine storm syndrome (CSS) has generally …

… cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to counter cytokine storm

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
… of cytokine storm; hence, various mechanisms, immunological pathways, and functions of
cytokines and … A thorough understanding of cytokines’ molecular pathways and their activation …

Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
… The inadequate immune response to the virus has been proposed as a possible
mechanism in the development of cytokine storms during SARS-CoV-2 infection [36,37]. As …

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
Cytokines play a pivotal role in these control mechanisms by regulating the immune
response, which they can, thus, amplify but also dissolve. By default, their comparatively short …

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
… role in the risk of a cytokine storm, and subsequently acute … It seems that “cytokine storm
phenomenon in elderly … the dysregulation of cytokine networks and possibly a cytokine storm in …

Highways to hell: Mechanism-based management of cytokine storm syndromes

SW Canna, RQ Cron - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
… as “cytokine storm” is … mechanisms and their interactions and treatments, but it must also
identify the signs and interventions that may broadly prevent CSS-induced immunopathology

Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
cytokine storm induction and progression, with profiles of cytokines released during cytokine
storm … This review focuses on pathophysiological mechanisms underlying cytokine storm

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
immunopathological characteristics of COVID-19 and focus on CS including the current
research status of the different cytokines … features of COVID-19, especially the CS; its mechanism