Cytokine storms, evolution and COVID-19

J Alcock, A Masters - Evolution, medicine, and public health, 2021 - academic.oup.com
… been proposed to treat a cytokine storm in coronavirus disease 2019 … In recent decades,
experimental therapies for cytokine storms … to the concept of cytokine storms and their treatment. …

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
… treatment options for the current coronavirus disease 2019 pandemic. … such immunotherapies
are already available for different treatment indications including those that target the IL-6

[HTML][HTML] The Society for Immunotherapy of Cancer perspective on regulation of interleukin-6 signaling in COVID-19-related systemic inflammatory response

FI Arnaldez, SJ O'Day, CG Drake, BA Fox… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
… , sometimes referred to as ‘cytokine storm’. One hallmark feature of … , and are a therapeutic
option in a number of inflammatory … agents as an option to prevent or treat cytokine release in …

COVID-19: more than a cytokine storm

G Riva, V Nasillo, E Tagliafico, T Trenti, P Comoli… - Critical care, 2020 - Springer
… of protective T cell immunity, while suppressing the emergent cytokine storm [7,8,9]. In fact, …
targeted immunotherapeutic drugs. During the last few years, cancer immunotherapy with …

COVID-19 infection: an overview on cytokine storm and related interventions

S Montazersaheb, SM Hosseiniyan Khatibi, MS Hejazi… - Virology journal, 2022 - Springer
… by elevated levels of pro-inflammatory cytokines, referred to as cytokine storm. Interleukins,
such as … Cytokine storm is defined as acute overproduction and uncontrolled release of pro-…

Immune signature of covid-19: In-depth reasons and consequences of the cytokine storm

P Niedźwiedzka-Rystwej, A Majchrzak… - International Journal of …, 2022 - mdpi.com
… has been associated with a cytokine storm (CS) syndrome in … CoV were also characterized
by a cytokine storm [6]. There are … the duality of the cytokine storm phenomenon in COVID-19, …

Targeting macrophages as a therapeutic option in coronavirus disease 2019

M Gracia-Hernandez, EM Sotomayor… - Frontiers in …, 2020 - frontiersin.org
… , including cytokine storm, tissue damage, and fibrosis (Figure 2). If M1-like function is
altered, excessive secretion of pro-inflammatory cytokines can lead to a “cytokine storm” that …

[HTML][HTML] Cytokine storm intervention in the early stages of COVID-19 pneumonia

X Sun, T Wang, D Cai, Z Hu, H Liao, L Zhi, H Wei… - Cytokine & growth factor …, 2020 - Elsevier
immunotherapy treatment at the time of diagnosis, in order to block the possibility of a
subsequent cytokine storm. … potential treatment options against the virus-induced cytokine storm. …

Sepsis, cytokine storms, and immunopathology: the divide between neonates and adults

KG Greenfield, VP Badovinac, TS Griffith… - …, 2021 - journals.aai.org
… a therapeutic option for adult … cytokines and chemokines partially overlap during the initial
stage of sepsis (2), resulting in a considerable amount of indecision on what immunotherapy in …

Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms

S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
… contributions of IL-6 signaling to the pathogenesis of several types of cytokine storms and
discuss potential therapeutic strategies for the management of cytokine storms, including those …