Vandetanib blocks the cytokine storm in SARS-CoV-2-infected mice

AC Puhl, GF Gomes, S Damasceno, EJ Fritch… - ACS …, 2022 - ACS Publications
… Combined, these results indicate that vandetanib reduces the cytokine storm rather than
reducing SARS-CoV-2 replication in the COVID-19 mouse model that was used in this study. …

[HTML][HTML] Cytokine storm–based mechanisms for extrapulmonary manifestations of SARS-CoV-2 infection

MDN Avila, R Das, J Kharlyngdoh, E Molina-Jijon… - JCI insight, 2023 - ncbi.nlm.nih.gov
… Viral illnesses like SARS-CoV-2 have pathologic effects on … of human cytokine storms resulting
from SARS-CoV-2/COVID-… , soluble IL-4Rα, or IL-6. The Zhx2 hypomorph state increased …

Repurposing of drugs targeting the cytokine storm induced by SARSCoV‐2

WH Ng, PCH Tang, S Mahalingam… - British Journal of …, 2023 - Wiley Online Library
… Anti-cytokine drugs have been used extensively to … SARS-CoV-2-induced ARDS, in
which the cytokine storm plays an immunopathological role. This minireview includes anti-cytokine

Targeting inflammation and cytokine storm in COVID-19

Q Huang, X Wu, X Zheng, S Luo, S Xu… - Pharmacological Research, 2020 - Elsevier
Cytokine storm represents an exaggerated immune response characterized by overproduction
of pro-inflammatory cytokines and chemokines such as IFN-γ, TNF-α, IL-6, IL… SARS-CoV-2 …

Pharmaco-immunomodulatory interventions for averting cytokine storm-linked disease severity in SARS-CoV-2 infection

A Kumar, A Sharma, NV Tirpude, S Sharma… - …, 2022 - Springer
… to occur due to the propensity of mutation in SARS-CoV-2 virus. The immune response plays
a … The severe COVID-19 infection persuaded cytokine storm that has been linked with acute …

Cytokine storm in COVID19: a neural hypothesis

A Ur, K Verma - ACS chemical neuroscience, 2020 - ACS Publications
… that SARS-CoV-2 mediated inflammation of nucleus tractus solitarius (NTS) may be responsible
for the cytokine storm in … Potential entry routes for the SARS COV-2 virus and the early …

[HTML][HTML] Intricate relationship between SARS-CoV-2–induced shedding and cytokine storm generation: A signaling inflammatory pathway augmenting COVID-19

MB Moftah, A Eswayah - Health Sciences Review, 2022 - Elsevier
… their ability to potentiate the cytokine storm during an episode of SARS-CoV-2 infection, often
… (ACE-2) as the main target for SARS-CoV-2 is highlighted in detail through a compilation of …

[HTML][HTML] Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2

Z Yao, Z Zheng, K Wu, Z Junhua - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
… Also, interleukins (IL-6, IL-23α, IL-10, IL-7, IL-1α, IL-1β) and interferon (IFN-α2, IFN2, IFN-γ) …
in MERS-Cov at 24 hours. A similar cytokine profile showed the cytokine storm served a …

Anti-SARS-CoV-2 and anti-cytokine storm neutralizing antibody therapies against COVID-19: Update, challenges, and perspectives

CM Batista, L Foti - International Immunopharmacology, 2021 - Elsevier
… against crucial cytokines. A) SARS-CoV-2 alveolar pneumonia induced by cytokine storm
The key cytokines are TNF-α IL-1β and IL-6. B) Antibody-based treatments against the key …

Cytokine storm: the primary determinant for the pathophysiological evolution of COVID-19 deterioration

R Chen, Z Lan, J Ye, L Pang, Y Liu, W Wu… - Frontiers in …, 2021 - frontiersin.org
… processes underlying how cytokine storms promote the … which cytokine storms contribute
to the deterioration of SARS-CoV-2 infection and describe the interaction between SARS-CoV-…