… of the different cytokines involved. We also discuss the induction, function, downstream
signaling, and existing and potential interventions for targeting these cytokines or related signal …

… Endothelial dysfunction is a result of cytokine storm, which activates the complement
cascade, increasing vascular permeability and vasculitis. Due to the wide expression of ACE2 …

… signaling pathways of cytokine storm and chart where along those pathways the drug is
effective. We find that the efficacy of S1P 1 R agonist in blunting cytokine storm is … -1 signaling. …

… of the cytokine storm; to describe the type, effects, and kinetics of cytokine production; and
to … As a result of these signaling cascades, transcription factors such as NFκB will induce the …

… that both transduce signals through the Jak-STAT signaling pathway. Receptor binding
results in the initiation of downstream signaling cascades, the result of which is the activation of …

… contributions of IL-6 signaling to the pathogenesis of several types of cytokine storms and
discuss … by which the immune response cascade is initiated and amplified to ultimate lead to a …

… Available evidence indicate that the so called “cytokine storm” an uncontrolled over-… of the
chemokine/chemokine-receptor system in the cytokine storm related to SARS-CoV-2 infection. …

… MyD88 signaling activates nuclear factor-κB (NF-κB), mitogen-activated protein kinase (…
(IRF) signaling cascades for transcriptional upregulation of several pro-inflammatory cytokines, …

… Current research is illuminating the cellular and molecular contributors of cytokine storm in
… generally on inflammatory cascades. However, what signaling cascades are targeted will …

… The cytokine release syndrome (CRS) is a complex cascade of multiple chemokines … Of
note, inhibition of this pathway would disrupt the signaling of multiple cytokines and maximize …