COVID-19 cytokine storm: targeting the appropriate cytokine

RQ Cron - The Lancet Rheumatology, 2021 - thelancet.com
… to dampen the cytokine storm syndrome to … cytokine storm syndrome was targeting interleukin-6
(IL-6). Early during the pandemic, IL-6 concentrations were noted to be elevated, and IL-6

Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome

P Mehta, RQ Cron, J Hartwell, JJ Manson… - The Lancet …, 2020 - thelancet.com
… In cytokine storm syndromes, the subcutaneous route is often … in the management of cytokine
storm syndromes and review the … improve the poor prognosis of cytokine storm syndromes. …

COVID-19 cytokine storm syndrome: a threshold concept

LYC Chen, TTT Quach - The Lancet Microbe, 2021 - thelancet.com
… -19 cytokine storm syndrome (COVID-19-CSS). Early in the pandemic, high levels of inflammatory
cytokines such as interleukin-6 (IL-6… Comparison with other cytokine storm syndromes, …

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

DE Leisman, L Ronner, R Pinotti, MD Taylor… - The Lancet …, 2020 - thelancet.com
… higher in patients with cytokine release syndrome (3110·… syndrome unrelated to COVID-19
(460 pg/mL, 216·3–978·7 pg/mL; p<0·0001). Our findings question the role of a cytokine storm

[HTML][HTML] Novel paediatric presentation of COVID-19 with ARDS and cytokine storm syndrome without respiratory symptoms

CE Pain, S Felsenstein, G Cleary, S Mayell… - The Lancet …, 2020 - ncbi.nlm.nih.gov
… To our knowledge, this case is the first paediatric patient reported with cytokine storm
syndrome during the COVID-19 pandemic presenting without respiratory symptoms on hospital …

[HTML][HTML] COVID-19 cytokine storm: the interplay between inflammation and coagulation

RJ Jose, A Manuel - The Lancet. Respiratory Medicine, 2020 - ncbi.nlm.nih.gov
… The pathophysiology of severe acute respiratory syndrome coronavirus 2 (… cytokines (tumour
necrosis factor [TNF], IL-6, and IL-1β) results in what has been described as a cytokine storm

Intravenous anakinra for cytokine storm syndromes

N Martis, A Audemard-Verger - The Lancet Rheumatology, 2020 - thelancet.com
… the use of intravenous anakinra in cytokine storm syndromes. Yvan Jamilloux and colleagues
con… term of cytokine storm syndromes. We feel that it is the concept of hyperinflammation …

[HTML][HTML] Cytokine storm syndrome in severe COVID-19

P Ruscitti, O Berardicurti, A Iagnocco… - Autoimmunity …, 2020 - ncbi.nlm.nih.gov
cytokine storm syndrome, … of cytokines, independent of the pathogenic trigger [25]. Thus, it
could be suggested that SARS-Cov2 is another possible cause of cytokine storm syndrome. In …

Intravenous anakinra for cytokine storm syndromes

Y Jamilloux, M Gerfaud-Valentin… - The Lancet Rheumatology, 2020 - thelancet.com
… the use of intravenous anakinra in cytokine storm syndromes. Yvan Jamilloux and colleagues
con… term of cytokine storm syndromes. We feel that it is the concept of hyperinflammation …

GM-CSF in the treatment of COVID-19: a new conductor in the pathogenesis of cytokine storm?

EG Favalli, R Caporali - The Lancet Rheumatology, 2020 - thelancet.com
… , known as cytokine release syndrome. A high concentration of interleukin-6 (IL-6) observed
in cytokine release syndrome, suggesting a pivotal role of this cytokine in the pathogenesis …