Failure of treatments based on the cytokine storm theory of sepsis: time for a novel approach

EJ Giamarellos-Bourboulis - Immunotherapy, 2013 - Taylor & Francis
… If agents that block the cytokine stormcytokines). Monocytes were stimulated with a variety
of purified bacterial ligands and heat-killed pathogens for the release of TNF-α, IL-1βand IL-6. …

[HTML][HTML] Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… systems consist of effector cells producing cytokines (interleukins, interferons, chemokines,
… chain reactions resulting in a massive release of cytokines. This may result in a drastic self-…

COVID-19 cytokine storm syndrome: a threshold concept

LYC Chen, TTT Quach - The Lancet Microbe, 2021 - thelancet.com
… Extending the umbrella of cytokine storm from rare diseases, … a discipline—eg, germ theory
revolutionised medicine in the late … We provide a comparison of how both germ theory and …

[HTML][HTML] Dynamics of a cytokine storm

HH Yiu, AL Graham, RF Stengel - 2012 - journals.plos.org
cytokine storm”, a dramatic increase in cytokine concentrations. The monoclonal antibody,
TGN1412, raised serum concentrations of both pro- and anti-inflammatory cytokinescytokines

[HTML][HTML] Cytokine storm in COVID-19 and the treatment simulacrum

A Karimi, SMR Hashemian - Biomedical and Biotechnology …, 2020 - journals.lww.com
… This finding can be seen confounding with the theory of cytokine storm, but further studies
in larger populations are required in order to discover the relation of COVID-19, ARDS, and …

[HTML][HTML] Histamine release theory and roles of antihistamine in the treatment of cytokines storm of COVID-19

OA Eldanasory, K Eljaaly, ZA Memish… - Travel medicine and …, 2020 - ncbi.nlm.nih.gov
… to cytokine storm and multi-organs failure. Thus, the use of antihistaminic medications could
result in a significant immune modulation which may help in the treatment of cytokine storm

[HTML][HTML] A cytokine/bradykinin storm comparison: what is the relationship between hypertension and COVID-19?

SA Wilczynski, CF Wenceslau… - American Journal of …, 2021 - ncbi.nlm.nih.gov
cytokine storm theory; and (ii) the bradykinin storm theory. From the cytokine storm perspective,
upregulation of cytokines … The newer bradykinin storm theory stresses the importance of …

Is a “cytokine storm” relevant to COVID-19?

P Sinha, MA Matthay, CS Calfee - JAMA internal medicine, 2020 - jamanetwork.com
… Nevertheless, the theory of the cytokine storm is based on these data, and the case for its
presence in COVID-19 seems weak. A more appropriate conclusion would be that in …

Cytokine storms, evolution and COVID-19

J Alcock, A Masters - Evolution, medicine, and public health, 2021 - academic.oup.com
… been proposed to treat a cytokine storm in coronavirus disease 2019 … In recent decades,
experimental therapies for cytokine storms … to the concept of cytokine storms and their treatment. …

[HTML][HTML] Hazards of the cytokine storm and cytokine-targeted therapy in patients with COVID-19

M Quirch, J Lee, S Rehman - Journal of medical Internet research, 2020 - jmir.org
… has been reported among patients with MERS, although the theory of cytokine storm has
been much less studied during the MERS outbreak. A study by Mahallawi et al [30] compared …