Preparing for the storm: mitigating the effect of SARS-CoV-2 induced hypercytokinemia

AB Rowaiye, OA Okpalefe, O Ajiroghene, OA Onuh… - 2020 - 95.179.195.156
… The production of multiple cytokines which causes cytokine storms in SARS-CoV-2
patients results in … Therefore, it holds great prospects in the treatment of COVID-19 [206]. …

Management Prospects for COVID-19: A Review

UA Jilani, I Rahman, SA Jilani - 2020 - techniumscience.com
… a variety of cytokines which are the predecessors of the cytokine storm, a hyperinflammatory
… selective cytokine inhibitors which either block the cytokine receptor or inhibit the cytokine

JAK-STAT signaling as an ARDS therapeutic target: Status and future trends

Y Zhang, Z Gao, F Jiang, H Yan, B Yang, Q He… - Biochemical …, 2023 - Elsevier
… Apoptosis of pulmonary epithelial further increases the release of inflammatory mediators
and creates a positive feedback of constant cytokine upregulation in the cytokine storm. …

Harnessing self-assembled nanoplatform of Dexamethasone and α-linolenic acid for high-efficiency inhibition of pulmonary cytokine storm and fibrosis in mice

H Liu, M Ji, Y Qin, Y Sun, H Wang, P Xiao, J Zhao… - Nano Today, 2024 - Elsevier
… We hypothesized that the co-administration of Dex and LNA will effectively alleviate pulmonary
cytokine storms and fibrosis, thus contributing to efficient management of these diseases. …

Prospects of novel and repurposed immunomodulatory drugs against acute respiratory distress syndrome (ARDS) associated with covid-19 disease

SS Nayak, A Naidu, SL Sudhakaran, S Vino… - Journal of personalized …, 2023 - mdpi.com
prospects of multi-target QSAR models allowing us to choose lead compounds that affect
multiple targets are very exciting, given that a cytokine storm … in the cytokine storm associated …

ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection

R Karki, SJ Lee, R Mall, N Pandian, Y Wang… - Science …, 2022 - science.org
… in severe COVID-19 to ward off deleterious effects of type I IFNs including cytokine storm. …
Together, our results show that ZBP1 drives cell death, cytokine storm, and lethality in β-…

Tackling the cytokine storm using advanced drug delivery in allergic airway disease

VK Patel, S Vishwas, R Kumar, G De Rubis… - Journal of Drug Delivery …, 2023 - Elsevier
cytokines that triggers an uncontrolled aberrant inflammatory response known as ‘cytokine
storm’. This phenomenon interferes with the signalling and production of cytokines over time …

[PDF][PDF] Biochemical and immunological aspects of COVID-19 infection and therapeutical intervention of oral low dose cytokine therapy: a systematic review

M Ratheesh, S Sheethal, SP Jose, S Rajan… - Immunopharmacol …, 2021 - academia.edu
… an excessive generation of proinflammatory cytokines known as cytokine storm and also,
the … and effectiveness of oral low dose cytokines against the virus as a therapeutic approach. …

[PDF][PDF] Liver injury associated with acute respiratory distress syndrome and the prospects of mesenchymal stromal cells therapy for liver failure

O Redko, A Dovgalyuk, A Dovbush, Z Nebesna… - therapy, 2021 - transplantology.org
… It causes liver dysfunction in critical patients through paracrine action of cytokines and other
… response syndrome and hypoxia as well as cytokine storm. Liver injury manifests itself as …

Taming the cytokine storm: Biomechanical analysis of selective restriction of conformational interdomainal junctions of CD4 coreceptor in a sepsis model

E Abbas, D Mofed, TZ Salem - Medical Hypotheses, 2022 - Elsevier
… release of inflammatory cytokines leading to a cytokine storm. During the early priming phase
of the septic response; T-helper 1 (Th-1) secrete a distinct proinflammatory cytokine profile …