The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine stormsunderlying molecular mechanisms is lacking. Recent studies demonstrate
a positive feedback loop between cytokine release and cell death pathways; certain cytokines

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… The development of CS from the various underlying basic mechanisms is a multifactorial …
cytokines leads to cytokine storm with the known potentially lethal courses [168]. …

The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved

F Coperchini, L Chiovato, G Ricci, L Croce… - Cytokine & Growth …, 2021 - Elsevier
cytokine/chemokine network is crucial in the onset and maintenance of the “cytokine storm”,
… a specific focus on their role in the cytokine storm and ultimately with their ability to predict …

Cytokine storm in COVID-19: An overview, mechanism, treatment strategies, and stem cell therapy perspective

NU Azmi, MU Puteri, D Lukmanto - … Sciences and Research, 2020 - scholarhub.ui.ac.id
… excessive amount of cytokine serum level (cytokine storm) has … Thus, the management of
the cytokine storm could be the … defense mechanism against infection, become an underlying

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

F Coperchini, L Chiovato, L Croce, F Magri… - Cytokine & growth factor …, 2020 - Elsevier
… During the MERS-CoV epidemics, several studies were aimed at understanding the
pathogenic mechanisms underlying the severe and often fatal pneumonia were performed. …

Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position paper

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
… Therefore, special considerations must guide management of patients at high risk of severe
COVID-19 disease and cytokine storm, including patients with underlying coronary artery …

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
… Although, the exact underlying mechanism of cytokine storm in elderly adults with severe
COVID-19 infection is far from clear. However, it is likely that dysregulation of the …

Highways to hell: Mechanism-based management of cytokine storm syndromes

SW Canna, RQ Cron - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
… these mechanisms interact and overlap. Likewise, the utility of a broad term such as “cytokine
storm” is … CSS research must improve our appreciation of its various mechanisms and their …

Targeting inflammation and cytokine storm in COVID-19

Q Huang, X Wu, X Zheng, S Luo, S Xu… - Pharmacological Research, 2020 - Elsevier
… Thus, it is urgent to find the underlying mechanism dominating such life-threatening complications.
… diverse mechanisms related to cytokine storm will be therapeutically relevant (Fig. 1). …

Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
cytokine storm induction and progression, with profiles of cytokines released during cytokine
storm … This review focuses on pathophysiological mechanisms underlying cytokine storm