Harnessing the immune system to overcome cytokine storm and reduce viral load in COVID-19: a review of the phases of illness and therapeutic agents

S Khadke, N Ahmed, N Ahmed, R Ratts, S Raju… - Virology journal, 2020 - Springer
… Severe manifestations of COVID-19 are caused by a combination of direct tissue injury
by viral replication and associated cytokine storm resulting in progressive organ damage. …

Quantification of cytokine storms during virus infections

S Yuan, SC Jiang, ZW Zhang, YF Fu, J Hu… - Frontiers in …, 2021 - frontiersin.org
… We retrieved the cytokine fold change (FC), viral load, and clearance rate data from these …
The best way to prevent a cytokine storm is to reduce the viral load or accelerate the virus

Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players …

P Frisoni, M Neri, S D'Errico, L Alfieri… - … Science, Medicine and …, 2022 - Springer
… the expression of multiple cytokines (IL-1β, IL-6, IL-10, IL-15, … strong and diffuse
immunoreactivity for IL-6 and IL-15 in the … Current evidence suggests that a cytokine storm is the …

The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… of HCQ might mitigate cytokine storm in patients with severe COVID-19. A small French
trial showed significant reductions in viral load and the duration of viral infection for COVID-19 …

Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates

S Reynard, E Gloaguen, N Baillet… - PLoS Neglected …, 2021 - journals.plos.org
… Here, we studied immune responses depending on the viral loads observed in infected
cynomolgus monkeys. An antiviral treatment allowed the reduction of viral load in some animals …

Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection

DM Muema, NA Akilimali, OC Ndumnego, SS Rasehlo… - BMC medicine, 2020 - Springer
… the cytokine storm in the early-treated individuals, suggesting a role for persistent viremia in
maintaining plasma cytokine levels, we checked if the duration to viral load suppression was …

Modelling of the innate and adaptive immune response to SARS viral infection, cytokine storm and vaccination

C Leon, A Tokarev, A Bouchnita, V Volpert - Vaccines, 2023 - mdpi.com
… leads to a shorter incubation period and higher maximal viral load. … viral loads. In order to
study the emergence and dynamics of cytokine storm, we consider proinflammatory cytokines

Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome

Y Sun, C Jin, F Zhan, X Wang, M Liang… - The Journal of …, 2012 - academic.oup.com
viral load correlated with these cytokines. … cytokine storm during the acute phase of disease
in SFTS patients and that the serum viral load correlated with substantially elevated cytokine

Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome

JS Kwon, MC Kim, JY Kim, NY Jeon, BH Ryu… - Journal of Clinical …, 2018 - Elsevier
… that a cytokine storm plays an important role in the pathophysiology of SFTS. However,
limited data have been published on the detailed kinetics of the viral load and cytokine profiles …

Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection

KKW To, IFN Hung, IWS Li, KL Lee… - Clinical Infectious …, 2010 - academic.oup.com
… atrophy in our deceased patients were compatible with a cytokine storm and have similarly
been reported in H5N1 infection [10]. Therefore, we studied the clinical characteristics, serial …