COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
… a potentially fatal disease that represents a … infection, but ultimately becomes a lethal disease
of hyperinflammation and respiratory dysfunction [1]. bySARS-CoV2 infection and disease

An interferon‐γ‐related cytokine storm in SARS patients

KJ Huang, IJ Su, M Theron, YC Wu… - Journal of medical …, 2005 - Wiley Online Library
… Since SARS-CoV infection can be fatal, and intensive inflammatory response is involved in
the disease process, we compared the cytokines between death and survival cases of SARS …

[HTML][HTML] COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
… the role of the cytokine storm in COVID-19 disease severity as well as potential therapeutic
approaches to ameliorate it. We also examine the role of inflammation in other diseases and …

[HTML][HTML] Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

KE Remy, M Mazer, DA Striker, AH Ellebedy… - JCI insight, 2020 - ncbi.nlm.nih.gov
… proinflammatory cytokine storm versus an immunosuppressive immunological endotype,
and determine whether there are changes in immune function during disease progression. To …

COVID-19 cytokine storm syndrome: a threshold concept

LYC Chen, TTT Quach - The Lancet Microbe, 2021 - thelancet.com
Cytokine storm from viral infection is well accepted in rare diseases such Epstein-Barr virus-…
Extending the umbrella of cytokine storm from rare diseases, such as EBV-HLH, to apply to …

[HTML][HTML] Cytokine storm syndrome in SARS-CoV-2 infections: a functional role of mast cells

B Hafezi, L Chan, JP Knapp, N Karimi, K Alizadeh… - Cells, 2021 - mdpi.com
… a specific disease, the cytokine storm syndrome is considered to be a culminating endpoint
to numerous diseases and conditions that occur during an attempt to fight off infections [1,4]. …

Targeting cytokine storm to manage patients with COVID-19: a mini-review

N Roshanravan, F Seif, A Ostadrahimi… - Archives of medical …, 2020 - Elsevier
… This infectious disease has been identified by the World Health … infection and inflammatory
cascade through various mechanisms with consequent release of pro-inflammatory cytokines

Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality

MG Ramos Muniz, M Palfreeman… - BioMed research …, 2018 - Wiley Online Library
… As stated, only female mice were challenged in this study due to our past experience in
infectious disease and obesity studies and prior associative studies with sepsis …

[HTML][HTML] Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis

AKG Melo, KM Milby, ALMA Caparroz, ACPN Pinto… - PloS one, 2021 - journals.plos.org
… moderately increase in those with virus infection or systemic inflammatory diseases. However,
its levels increase significantly in cases of generalized infection, mainly bacterial or fungal …

Targeting inflammation and cytokine storm in COVID-19

Q Huang, X Wu, X Zheng, S Luo, S Xu… - Pharmacological Research, 2020 - Elsevier
… also confirmed the correlation of cytokine storm syndrome and disease severity as well
as … and cytokine storm highlights the necessity of early identification of cytokine storm and …