The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19

A Attiq, LJ Yao, S Afzal, MA Khan - International immunopharmacology, 2021 - Elsevier
… Initially, the threonine-derived kinases (PKR) prompt an innate immune response, terminating
the translation processes to prevent viral replication in infected cells. Secondly, dsRNA …

Shelter from the cytokine storm: Healthy living is a vital preventative strategy in the COVID-19 era

R Arena, S Bond, IR Calvo, L Lebowicz… - Progress in …, 2022 - Elsevier
… from a ‘typical’ immune response. Cytokine and/or immune system hyperactivity has been
… -19 infection involves the innate and adaptive components of the immune system. Following …

Innate immune responses to highly pathogenic coronaviruses and other significant respiratory viral infections

H Ahmed-Hassan, B Sisson, RK Shukla… - … in immunology, 2020 - frontiersin.org
… Accumulating data suggest that the innate anti-viral response and adaptive immunity may
contribute to a cytokine storm leading to systemic hyper inflammation and exacerbation of the …

Innate immune evasion by SARS‐CoV‐2: comparison with SARS‐CoV

A Bouayad - Reviews in medical virology, 2020 - Wiley Online Library
… of NLRP3 inflammasome and induction of a cytokine storm. A comparison with SARS-CoV …
suppress innate responses that act prior to the protective responses of the adaptive immune

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue

X Yongzhi - Emerging microbes & infections, 2021 - Taylor & Francis
… The reasons are that estrogens can make women’sa more effective innate and adaptive
immune response and a less pronounced hyperinflammation. Besides, estrogens can effectively …

Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

JLB Simões, HF Basso, GC Kosvoski, J Gavioli… - International …, 2021 - Elsevier
… In mild situations, only the innate immune response is … As a result, both the innate and
adaptive immune systems are … Thus, with the virus installed in the host cell, the innate immune

Innate immunity in protection and pathogenesis during coronavirus infections and COVID-19

RKS Malireddi, BR Sharma… - … Review of Immunology, 2024 - annualreviews.org
cytokines and the cellular components of the innate immune … inflammatory cell death, cytokine
storm, and organ damage … for bridging the innate and adaptive immune responses, the DC …

Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19

P Laurent, C Yang, AF Rendeiro… - … immunology, 2022 - science.org
… response of macrophages to various innate stimuli. In the lungs … patients that did not produce
a cytokine storm. In contrast, in … lung macrophages to induce a cytokine storm. This model is …

… immunity trained by coronavirus infections, DAMP stimulations and regulated by anti-oxidant NRF2 may contribute to inflammations, myelopoiesis, COVID-19 cytokine …

Y Shao, J Saredy, K Xu, Y Sun, F Saaoud… - … in immunology, 2021 - frontiersin.org
… , as we reported, with four innate immune features including upregulation of EC adhesion …
in promoting EC activation and other innate and adaptive immune responses; third, human …

Innate and adaptive immune responses to fungi in the airway

KR Bartemes, H Kita - Journal of Allergy and Clinical Immunology, 2018 - Elsevier
… A type II interferon, IFN-γ is a cytokine that is required for innate and adaptive immunity
against viral, bacterial, and protozoal infections. IFN-γ has been shown to be an important …