Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID19 disease

MK Vakil, Y Mansoori, GRL Al‐Awsi… - Journal of Medical …, 2022 - Wiley Online Library
… (TLRs) mainly TLR3, TLR7, and TLR9 have been related to the COVID-19 severe …
proinflammatory cytokines, cytokine receptors, and TLRs predispose patients to COVID-19 disease …

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

D Darif, I Hammi, A Kihel, IEI Saik, F Guessous… - Microbial …, 2021 - Elsevier
… in COVID-19. Here, we review the current understanding of pro-inflammatory cytokines
associated with COVID-19 … In view of this IL-6 increase, antibodies that block the IL-6 receptor are …

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

F Coperchini, L Chiovato, L Croce, F Magri… - Cytokine & growth factor …, 2020 - Elsevier
… acute respiratory infection named COVID-19, which is causing a … COVID-19 and previously
identified beta-coronavirus infections. Available evidence indicate that the so called “cytokine

[PDF][PDF] Kinins and cytokines in COVID-19: a comprehensive pathophysiological approach

F van de Veerdonk, MG Netea, M van Deuren… - 2020 - pdfs.semanticscholar.org
… angioedema via B1 and B2 receptors is an important feature of COVID-19, resulting in a …
B1 and B2 receptors might have an ameliorating effect on disease caused by COVID-19. This …

Role of innate and adaptive cytokines in the survival of COVID-19 patients

…, M Álvarez-Mon, COVID-19 HUPA Group - International journal of …, 2022 - mdpi.com
… We also calculated the ratio of the serum concentration of each cytokine and cytokine
receptor studied between the surviving and non-surviving severe COVID-19 patients. We found …

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

C Zhang, Z Wu, JW Li, H Zhao, GQ Wang - International journal of …, 2020 - Elsevier
… Taken together, we have a reasonable hypothesis that cytokine storms play an important
role in severe COVID-19 cases. Therefore, neutralising key inflammatory factors in cytokine

COVID-19 cytokine storm: The anger of inflammation

M Mahmudpour, J Roozbeh, M Keshavarz, S Farrokhi… - Cytokine, 2020 - Elsevier
… a burst of inflammatory cytokine release through dysregulation … II/AT1R axis), attenuation
of Mas receptor (ACE2/MasR axis), … the cytokine storm in order to prevent and treat COVID-19

The cytokine storm and COVID19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
cytokine storm in severe COVID-19. Therefore, here, we have discussed the current findings
and treatment strategies for the cytokine storm in severe COVID-19… IL-1 receptor antagonists …

COVID-19, cytokines, inflammation, and spices: How are they related?

AB Kunnumakkara, V Rana, D Parama, K Banik… - Life sciences, 2021 - Elsevier
Cytokine storm is the exaggerated … of COVID-19 disease as well as associated complications
and mortality. Therefore, targeting the cytokine storm might help in reducing COVID-19-…

COVID-19 infection: an overview on cytokine storm and related interventions

S Montazersaheb, SM Hosseiniyan Khatibi, MS Hejazi… - Virology journal, 2022 - Springer
… However, it should be noted that ACE2, as a defined receptor of the COVID-19 virus, is
absent on T cells (11), proposing that the reduced level of T counts in affected patients is likely …