… The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded
by 11 distinct genes in humans and mice. IL-1–type cytokines … of circulating interleukin 1 in …

Publisher Summary Interleukin-1 (IL-1) and tumor necrosis factor (TNF) participate in self-augmentation
induction mechanisms. Recombinant human IL-1 and TNF are each capable of …

… cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-1 is the prototype
of the pro-inflammatory cytokines … IL-1 is also the prototypic “alarm“ cytokine in that it brings …

… IL 1 is a highly inflammatory molecule and stimulates the … IL 1 also acts synergistically with
other cytokines, particularly tumor necrosis factor. The multitude of biological responses to IL 1 …

… The synthesis, processing, secretion and activity of IL-1, particularly IL-Iβ, are tightly
regulated events. A unique aspect of cytokine biology is the naturally occurring IL-1 receptor …

… More than any other cytokine family, the interleukin (IL)-1 family is closely linked to the
innate immune response. This linkage became evident upon the discovery that the cytoplasmic …

… IL-1 (IL-la or IL-1P) is the prototypic “multifunctional” cytokine. Unlike the lymphocyte and …
-1 receptor signaling or that compensatory cytokines are used by these mice. INTERLEUKIN-1 …

… -1 receptor antagonist (IL-1Ra or IL-1RN). This review is an insight into the different types of
cytokines belonging to IL-1 family… on the role of Interleukin-1 (IL-1) family of cytokines and its …

… ) cytokines in vitro and in vivo as well as histopathological changes in the lungs and GI tract
of mice. Therapeutic agents which modify IL-1 cytokines (… novel IL-1 cytokines and assesses …

… IL-1 was one of the earliest identified members of a group of peptides now known as the
cytokines, which exhibit diverse and overlapping activities on biological functions, largely …