NF-κB inhibition delays DNA damage–induced senescence and aging in mice

JS Tilstra, AR Robinson, J Wang… - The Journal of …, 2012 - Am Soc Clin Investig
… senescence and oxidative damage, including DNA and protein damage, revealing … damage.
Our findings strongly suggest that inhibitors of the IKK/NF-κB pathway may delay damage

Exacerbation of damage and altered NF-κB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury

PG Sullivan, AJ Bruce-Keller… - Journal of …, 1999 - Soc Neuroscience
… of MnSOD, we compared cortical damage in MnSOD-overexpressing mice with that in wild-…
mice. Lastly, to address the putative mechanisms involved, we evaluated activation of NF-κB

Signals from within: the DNA-damage-induced NF-κB response

S Janssens, J Tschopp - Cell Death & Differentiation, 2006 - nature.com
… leading to DNA damage-induced NF-κB activation are poorly … of distinct DNA damage-induced
NF-κB signalling pathways. … mice did not reveal any functional link between p53 and NF-…

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

R Saggu, T Schumacher, F Gerich, C Rakers… - Acta neuropathologica …, 2016 - Springer
… carotid arteries in isoflurane-anaesthetised mice [13]. Informed by … Mice from each litter were
randomised to either microcoil … Mice were excluded if visual damage to the carotid arteries …

Protocatechuic acid ameliorates lipopolysaccharide‐induced kidney damage in mice via downregulation of TLR‐4‐mediated IKBKB/NFκB and MAPK/Erk signaling …

AAA Salama, R Elgohary… - Journal of Applied …, 2023 - Wiley Online Library
… acute kidney damage in mice. Forty male Swiss mice were allocated in four groups as follows:
normal control group; LPS (250 μg/kg, ip)-induced kidney injury group; LPS-injected mice

Blackberry extract inhibits UVB-induced oxidative damage and inflammation through MAP kinases and NF-κB signaling pathways in SKH-1 mice skin

SP Divya, X Wang, P Pratheeshkumar, YO Son… - Toxicology and applied …, 2015 - Elsevier
mouse skin from UVB-induced oxidative damage and inflammation by modulating MAP kinase
and NF-κB … efficacy of BBE against UVB-induced skin damage. Further long term in vivo …

DNA damage‐dependent NFκB activation: NEMO turns nuclear signaling inside out

KW McCool, S Miyamoto - Immunological reviews, 2012 - Wiley Online Library
… Critical insight came from reconstitution experiments with 1.3E2 (NEMO)-deficient mouse
pre-B cell system that we obtained from Alan Israel’s group. In particular, we obtained a robust …

Vascular endothelial cell–specific NF-κB suppression attenuates hypertension-induced renal damage

N Henke, R Schmidt-Ullrich, R Dechend… - Circulation …, 2007 - Am Heart Assoc
… To induce hypertension with target-organ damage, we fed mice a high-salt diet and N(omega)-nitro-l-arginine-methyl-ester
(L-NAME) and infused angiotensin (Ang) II. This treatment …

Ursolic acid ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney by inhibiting the STAT3 and NF-κB activities

JQ Ma, J Ding, ZH Xiao, CM Liu - International Immunopharmacology, 2014 - Elsevier
… in the kidneys of CCl 4 treated mice. Male ICR mice were injected with CCl 4 with or without
… by both diagnostic indicators of kidney damage and histopathological analysis. Moreover, …

[PDF][PDF] Roles of NF-kappa B in central nervous system damage and repair

L Yang, LY Tao, XP Chen - Neuroscience bulletin, 2007 - researchgate.net
… Regular expressions of NFκB p50, NF-κB p65 and tumor necrosis factor alpha (TNFα) were
observed in the mouse brain in each period after experimental thermal ablation injury. The …