Chronic kidney disease and SGLT2 inhibitors: a review of the evolving treatment landscape

CW Mende - Advances in therapy, 2022 - Springer
… with or without T2D), respectively, with DAPA-CKD being the first trial to show a reduced risk
… A post hoc analysis of the RENAAL study found that each 50% reduction in albuminuria with …

Cardiovascular outcomes of glucose lowering therapy in chronic kidney disease patients: a systematic review with meta-analysis

A Kamdar, R Sykes, A Morrow… - Reviews in …, 2021 - eprints.gla.ac.uk
DAPA-CKD trial was discontinued by the data monitoring committee when an interim analysis
… Further trials with prespecified analysis would be required to establish this finding fully. …

[HTML][HTML] Effects of dapagliflozin on volume status and systemic hemodynamics in patients with CKD without diabetes: results from DAPASALT and DIAMOND

T Sen, R Scholtes, PJ Greasley, D Cherney… - Diabetes, obesity & …, 2022 - ncbi.nlm.nih.gov
… The analyses of the DAPASALT study were pre-specified and the analyses of the DIAMOND
… In summary, SGLT2 inhibitor dapagliflozin decreased blood pressure despite no clear …

SGLT2 inhibition in chronic kidney disease: a preventive strategy against acute kidney injury at the same time?

S Hasegawa, M Nangaku - Kidney International, 2022 - Elsevier
… In conclusion, the pre-specified analysis of the DAPA-CKD trial has confirmed that … of an
abrupt decline in kidney function in patients with CKD. Although further studies are needed to …

The Why and How of SGLT2 Inhibitors in CKD: A Practical Approach

M Borkum, A Levin - Canadian Journal of General Internal …, 2022 - utpjournals.press
… studies (CREDENCE, DAPA and EMPA CKD, the latter of … analysis of DAPA-CKD showed
no significant interaction of treatment effects (including efficacy and safety outcomes) by CKD

… optimized renin-angiotensin system blockade among IgA nephropathy patients at high-risk of disease progression: A network meta-analysis of randomized controlled …

Q Tan, H Xue, X Ni, L Fan, W Du - European Journal of Internal Medicine, 2023 - Elsevier
… In addition, the DAPA-CKD study did not adopt 24 h … hence we considered this population
in DAPA-CKD to be eligible for … A pre-specified analysis of the DAPA-CKD trial demonstrates …

SGLT-2 inhibitors in non-diabetic patients: a systematic review

CM Almeida - 2022 - repositorio.ul.pt
… The DAPA-CKD subgroup analysis included a group of patients with IgA nephropathy
and another with focal segmental glomerulosclerosis (FSGS). There were 270 subjects with …

Effect of dapagliflozin on anaemia in DAPA‐HF

…, DAPA‐HF Investigators and Committees - European journal of …, 2021 - Wiley Online Library
… therapy) and the pre-specified secondary endpoints of total … summary score (OSS) and
clinical summary score (CSS). … In this post-hoc analysis of DAPA-HF we found that anaemia …

Pharmacotherapy of hypertension in patients with pre-dialysis chronic kidney disease

C Loutradis, P Sarafidis - Expert Opinion on Pharmacotherapy, 2020 - Taylor & Francis
… In the pre-specified renal outcome analysis, the benazepril-amlodipine group was shown
to have a slower decrease in eGFR rate (−0.88 vs −4.22 mL/min/1.73m 2 per year) although it …

Absolute treatment effects of novel antidiabetic drugs on a composite renal outcome: meta-analysis of digitalized individual patient data

M Brockmeyer, C Parco, KG Vargas, R Westenfeld… - Journal of …, 2024 - Springer
… a pre-specified … in DAPA-HF [11, 27] (2-year meta-number needed to treat of 21) and
EMPEROR-REDUCED [12, 27] (2-year meta-number needed to treat of 15), the present analysis