Efficacy of dapagliflozin in heart failure with reduced ejection fraction according to body mass index

C Adamson, PS Jhund, KF Docherty… - European journal of …, 2021 - Wiley Online Library
… Analysis by BMI category <30 kg/m 2 compared with ≥30 kg/m 2 was a pre-specified
subgroup analysis in DAPA-HF but we provide more granularity about the effect of dapagliflozin

Impact of Dapagliflozin on the left ventricular diastolic function in Diabetic patients with heart failure complicating Cardiovascular Risk factors

F Soga, H Tanaka, K Tatsumi, Y Mochizuki… - Internal …, 2021 - jstage.jst.go.jp
… clinical trial, DAPA-HF, which used the SGLT2 inhibitor dapagliflozin and included 4,744 …
worsening HF or death from cardiovascular causes was significantly lower in the dapagliflozin

Effect of sacubitril/valsartan combined with dapagliflozin on long-term cardiac mortality in heart failure with reduced ejection fraction

U Karabulut, K Keskin, D Karabulut, E Yiğit… - Angiology, 2022 - journals.sagepub.com
Dapagliflozin is an SGLT-2 inhibitor used as an oral antidiabetic drug. The DAPA-HF study
showed that dapagliflozin significantly decreased hospitalization due to HF and cardiac …

Current Role of Dapagliflozin in Clinical Practice.

AH Zargar, AA Trailokya, S Ghag, R Pawar… - The Journal of the …, 2021 - europepmc.org
DAPA HF evaluated the efficacy and safety of the dapagliflozin in patients with HF and …
Patients with symptomatic HF due to reduced ejection fraction treated with dapagliflozin had …

Cost-effectiveness of dapagliflozin for treatment of patients with heart failure with reduced ejection fraction

JT Parizo, JD Goldhaber-Fiebert, JA Salomon… - JAMA …, 2021 - jamanetwork.com
… SOC rates multiplied by the DAPA-HF HR (eMethods 3 in … dapagliflozin arm. We modeled
an adverse event rate based on DAPA-HF; we assumed patients discontinued dapagliflozin

Effects of dapagliflozin on mortality in patients with chronic kidney disease: a pre-specified analysis from the DAPA-CKD randomized controlled trial

HJL Heerspink, CD Sjöström, N Jongs… - European heart …, 2021 - academic.oup.com
DAPA-CKD trial, we determined the effects of dapagliflozin … of the DAPA-CKD trial, we
demonstrated that dapagliflozin … The benefits of dapagliflozin on overall mortality were driven …

The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction

C Withaar, LMG Meems… - Cardiovascular …, 2021 - academic.oup.com
… We therefore studied the effects of the GLP-1 RA liraglutide (Lira) and the SGLT2i dapagliflozin
(Dapa) on cardiac structure and function in a novel cardiometabolic HFpEF mouse model…

Effect of dapagliflozin on health status in patients with preserved or mildly reduced ejection fraction

MN Kosiborod, AS Bhatt, BL Claggett… - Journal of the American …, 2023 - jacc.org
… Patients were stratified by KCCQ-TSS tertiles; Cox models examined effects of dapagliflozin
on clinical outcomes. We evaluated the effects of dapagliflozin on KCCQ-TSS, Physical …

Effects of dapagliflozin on hospitalizations in patients with chronic kidney disease: a post hoc analysis of DAPA-CKD

M Schechter, N Jongs, GM Chertow… - Annals of internal …, 2023 - acpjournals.org
effects of SGLT2 inhibition had not previously been studied in this population. Dapagliflozin
… In this post hoc analysis of the DAPA-CKD trial, we assessed the effects of dapagliflozin on …

Dapagliflozin for heart failure with preserved ejection fraction: will the DELIVER study deliver?

DM Williams, M Evans - Diabetes Therapy, 2020 - Springer
… other key trials evaluating dapagliflozin: The DAPA-HF study [18] and the DAPA-CKD study
[… those of the DAPA-HF study and determine whether the impact of dapagliflozin on the rate of …