Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction: the DEFINE-HF trial

ME Nassif, SL Windsor, F Tang, Y Khariton, M Husain… - Circulation, 2019 - Am Heart Assoc
… These beneficial effects of dapagliflozin in heart failure with reduced ejection … dapagliflozin
or placebo. One patient in each of the dapagliflozin and placebo groups died during the study

Effects of dapagliflozin on prevention of major clinical events and recovery in patients with respiratory failure because of COVID‐19: Design and rationale for the …

M Kosiborod, O Berwanger, GG Koch… - Diabetes, Obesity …, 2021 - Wiley Online Library
… (with and without atherosclerotic cardiovascular disease), heart failure and chronic
kidney disease, and may provide similar organ protection in high-risk patients with COVID-19. …

Efficacy of dapagliflozin in the treatment of HFrEF with obstructive sleep apnea syndrome (DAHOS study): study protocol for a multicentric, prospective, randomized …

L Xie, S Song, S Li, Q Wei, H Liu, C Zhao, F Yu, J Tong - Trials, 2023 - Springer
… We hypothesized that dapagliflozin, as a new star in the treatment of heart failure, could
improve sleep apnea in heart failure patients. In our study, patients with heart failure complicated …

The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction

C Withaar, LMG Meems… - Cardiovascular …, 2021 - academic.oup.com
… In addition, several studies have also reported improved diastolic function in animals and …
therefore studied the effects of the GLP-1 RA liraglutide (Lira) and the SGLT2i dapagliflozin (…

Cost-effectiveness of dapagliflozin for treatment of patients with heart failure with reduced ejection fraction

JT Parizo, JD Goldhaber-Fiebert, JA Salomon… - JAMA …, 2021 - jamanetwork.com
… that dapagliflozin provided similar value across heart failure … health status impairment due
to heart failure, the cost per QALY … evaluation study demonstrates that dapagliflozin provides …

Metabolomic profiling of the effects of dapagliflozin in heart failure with reduced ejection fraction: DEFINE-HF

S Selvaraj, Z Fu, P Jones, LC Kwee, SL Windsor… - Circulation, 2022 - Am Heart Assoc
… Among the 234 participants included in the current study (Table 1), 121 were randomized
to dapagliflozin and 113 to placebo. The average age was 62±11 years, 25% were women, …

Effect of dapagliflozin on outpatient worsening of patients with heart failure and reduced ejection fraction: a prespecified analysis of DAPA-HF

KF Docherty, PS Jhund, I Anand, O Bengtsson… - Circulation, 2020 - Am Heart Assoc
… occurring in the same time window between 2 study visits, the beneficial effect of
dapagliflozin in comparison with placebo was not modified with a HR of 0.71 (95% CI, 0.60–0.85). …

Dapagliflozin reduces pulmonary vascular damage and susceptibility to atrial fibrillation in right heart disease

C Dai, B Kong, W Shuai, Z Xiao, T Qin, J Fang… - … Heart Failure, 2023 - Wiley Online Library
… In this research, we observed that dapagliflozin can reduce pulmonary vascular damage
and RHD in MCT-exposed rats. In addition, it can also reduce the susceptibility to AF caused by …

Effects of dapagliflozin according to the heart failure collaboratory medical therapy score: insights from DAPA-HF

JH Butt, P Dewan, EM DeFilippis, T Biering-Sørensen… - Heart Failure, 2022 - jacc.org
Failure) trial, we evaluated the effect of the SGLT2 inhibitor, dapagliflozin, versus placebo,
according to a modified Heart … With respect to safety and tolerability, study drug …

DELIVER Trial: For HF Patients, Dapagliflozin Beneficial Regardless of Ejection Fraction.

B Park - Medical Bag, 2022 - go.gale.com
DELIVER phase 3 trial. “Earlier heart failure with preserved ejection fraction trials have shown
… in the highest left ventricular ejection fraction but with dapagliflozin results are consistent …