[HTML][HTML] Heart failure, investigator-reported sleep apnea and dapagliflozin: A patient-level pooled meta-analysis of DAPA-HF and DELIVER

JH Butt, K Jering, RA de Boer, BL Claggett… - … of Cardiac Failure, 2024 - Elsevier
… clinical trials in HF, both of which randomized participants to treatment with dapagliflozin
or placebo and which were pooled for analysis across the range of left ventricular ejection …

Dapagliflozin: a review in symptomatic heart failure with reduced ejection fraction

HA Blair - American Journal of Cardiovascular Drugs, 2021 - Springer
heart failure with reduced ejection fraction (HFrEF). The cardiovascular (CV) benefits of
dapagliflozin were first observed in the DECLARE-TIMI 58 trial, in which dapagliflozin 10 mg/day …

Efficacy and safety of dapagliflozin according to aetiology in heart failure with reduced ejection fraction: insights from the DAPA‐HF trial

JH Butt, JC Nicolau, S Verma… - … of heart failure, 2021 - Wiley Online Library
… receiving optimal guideline-directed medical therapy and provide further evidence for
dapagliflozin as a new treatment option for HFrEF. Interestingly, despite the different mortality and …

Effect of dapagliflozin on ventricular arrhythmias, resuscitated cardiac arrest, or sudden death in DAPA-HF

JP Curtain, KF Docherty, PS Jhund… - European heart …, 2021 - academic.oup.com
dapagliflozin on the incidence of ventricular arrhythmias and sudden death in patients with
heart failure … DAPA-HF was a randomized, double-blind, controlled trial in patients with HFrEF…

The role of dapagliflozin in the management of heart failure: an update on the emerging evidence

M Gupta, S Rao, G Manek, GC Fonarow… - … and clinical risk …, 2021 - Taylor & Francis
… -CKD trial broaden the utility of dapagliflozin as a therapeutic option in patients with advanced
kidney disease… the existing evidence on dapagliflozin in heart failure with reduced ejection …

Dapagliflozin improves heart failure symptoms and physical limitations across the full range of ejection fraction: pooled patient-level analysis from DEFINE-HF and …

ME Nassif, SL Windsor, K Gosch… - … : Heart Failure, 2023 - Am Heart Assoc
… Using a pooled analysis from 2 randomized trials of patients with HF, we demonstrate that
SGLT2 inhibitor dapagliflozin produced significant and clinically meaningful improvements in …

Efficacy and safety of dapagliflozin in patients with type 2 diabetes and concomitant heart failure

M Kosiborod, I Gause-Nilsson, J Xu… - Journal of diabetes and …, 2017 - Elsevier
patients randomized to dapagliflozin 10 mg or placebo with a history of HF were pooled from
five clinical trials. … -controlled trials was to assess the efficacy and safety of dapagliflozin 10 …

Projected clinical benefits of dapagliflozin in patients with heart failure with preserved ejection fraction

M Montero-Pérez-Barquero… - Future …, 2023 - Taylor & Francis
… Therefore, in the light of the results of the DELIVER trial, in which the benefits of dapagliflozin
were seen irrespective of baseline NT-proBNP concentrations [11,31], our data strongly …

Dapagliflozin in black and white patients with heart failure across the ejection fraction spectrum

JH Butt, KF Docherty, BL Claggett, AS Desai, JC Fang… - Heart Failure, 2023 - jacc.org
… of 2 trials comparing dapagliflozin to placebo in patients with … we provide a detailed report
of the effects of dapagliflozin on … , in Black compared with White patients across the range of …

[HTML][HTML] DAPA-HF trial: dapagliflozin evolves from a glucose-lowering agent to a therapy for heart failure

E Kaplinsky - Drugs in Context, 2020 - ncbi.nlm.nih.gov
Failure) trial enrolled 4744 patients with HF and reduced ejection fraction (EF) who … of
dapagliflozin (a SGLT2 inhibitor) or placebo. The DAPA-HF trial clearly showed that dapagliflozin