Dapagliflozin versus placebo on left ventricular remodeling in patients with diabetes and heart failure: the REFORM trial

JSS Singh, IR Mordi, K Vickneson, A Fathi… - Diabetes …, 2020 - Am Diabetes Assoc
… was to determine the cardiac effects of dapagliflozin in patients with HF and … ejection fraction
[EF]) using cardiac MRI (CMR). Fifty-six patients were randomized 1:1 to either dapagliflozin

Positive effect of dapagliflozin on left ventricular longitudinal function for type 2 diabetic mellitus patients with chronic heart failure

H Tanaka, F Soga, K Tatsumi, Y Mochizuki… - Cardiovascular …, 2020 - Springer
… of heart failure (HF) in patients with reduced ejection fraction (HFrEF) and with … ejection
fraction (HFpEF), as well as cardiovascular disease [1, 2]. Diabetes-related cardiomyopathy is …

SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: a meta-analysis of the EMPEROR-Reduced and DAPA-HF trials

F Zannad, JP Ferreira, SJ Pocock, SD Anker, J Butler… - The Lancet, 2020 - thelancet.com
… The effects of empagliflozin and dapagliflozin on hospitalisations for heart failure were
consistent in the two independent trials and suggest that these agents also improve renal …

Combined treatment with sacubitril/valsartan plus dapagliflozin in patients affected by heart failure with reduced ejection fraction

J Jiang, J Gao, X Zhang, Y Li, H Dang, Y Liu… - … in Cardiovascular …, 2023 - frontiersin.org
… (HF) with reduced ejection fraction (HFrEF) has not been widely reported. In this article, the
dapagliflozin and sacubitril/valsartan respect to improvements of cardiac function in patients

Targeted metabolomic profiling of dapagliflozin in heart failure with preserved ejection fraction: the PRESERVED-HF trial

S Selvaraj, S Patel, AJ Sauer, RW McGarrah, P Jones… - Heart Failure, 2024 - jacc.org
… in Patients with HF with Reduced Ejection Fraction) trial. Using targeted metabolomics, we
found that dapagliflozin … fatty acid biology with SGLT2is in patients with HFrEF. Leveraging the …

… in Heart Failure With Preserved Ejection Fraction: Insights From the Cardiac and Metabolic Effects of Dapagliflozin in Heart Failure With Preserved Ejection Fraction …

A Tada, D Burkhoff, JA Naser, T Harada, B Pourmussa… - Circulation, 2024 - ahajournals.org
… in patients with HFpEF, but the mechanisms remain unclear. This study tested the hypothesis
that Dapagliflozin would … and venous capacitance during exercise in patients with HFpEF. …

Effects of dapagliflozin on heart failure hospitalizations according to severity of inpatient course: Insights from DELIVER and DAPA‐HF

S Chatur, T Kondo, BL Claggett… - … of heart failure, 2023 - Wiley Online Library
dapagliflozin resulted in significant reductions in first and recurrent HF hospitalizations in
patients with HF across the left ventricular ejection fraction … the effects of dapagliflozin on HF …

Dapagliflozin impact on the exercise capacity of non-diabetic heart failure with reduced ejection fraction patients

J Reis, AR Teixeira, AV Gonçalves, RI Moreira… - Journal of Clinical …, 2022 - mdpi.com
patients with HF with reduced left ventricular ejection fraction … online randomization platform
and patients were randomized … Patients were randomly assigned to take Dapagliflozin 10 …

Effects of dapagliflozin according to QRS duration across the spectrum of left ventricular ejection fraction: An analysis of DAPA‐HF and DELIVER

A Abdin, T Kondo, M Böhm, PS Jhund… - … of Heart Failure, 2024 - Wiley Online Library
patients with a paced rhythm and cardiac resynchronization therapy. Overall, 4008
patients had heart failure (HF) with reduced ejection fraction (… /preserved ejection fraction (HFmrEF/…

Dapagliflozin in heart failure with reduced ejection fraction: a real-world study

Z Hao, Y Zhang - Cardiovascular Innovations and Applications, 2022 - scienceopen.com
dapagliflozin significantly decreased the risk of … heart failure or death from cardiovascular
causes in patients with HFrEF [1]. We believe that dapagliflozin is safe and effective in patients