Influence of NT-proBNP on efficacy of dapagliflozin in heart failure with mildly reduced or preserved ejection fraction

PL Myhre, M Vaduganathan, BL Claggett, ZM Miao… - Heart Failure, 2022 - jacc.org
dapagliflozin 10 mg daily or placebo, and showed that dapagliflozin reduced the composite
of cardiovascular … safety of dapagliflozin according to baseline NT-proBNP concentrations in …

Efficacy and safety of dapagliflozin in heart failure with reduced ejection fraction according to N-terminal pro-B-type natriuretic peptide: insights from the DAPA-HF trial

JH Butt, C Adamson, KF Docherty… - … : Heart Failure, 2021 - Am Heart Assoc
… inhibitor dapagliflozin, compared with placebo, led to significant reductions … cardiovascular
death and heart failure hospitalization. We examined the effect of dapagliflozin on NT-proBNP

[HTML][HTML] NT-proBNP response to heart failure therapies: an imperfect surrogate

JW Cunningham, PL Myhre - Journal of the American College of …, 2021 - jacc.org
… Status in Patients with HF … NT-proBNP after 12 weeks from dapagliflozin compared to
placebo (5), and in the CANDLE trial, NT-proBNP changes were small and comparable to patients

Prognostic importance of NT-proBNP and effect of empagliflozin in the EMPEROR-reduced trial

JL Januzzi Jr, F Zannad, SD Anker, J Butler… - Journal of the American …, 2021 - jacc.org
NT-proBNP concentrations were associated with greater risk for adverse heart failure or …
When added to standard HF care, both empagliflozin and dapagliflozin reduced rates of …

Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction: the DEFINE-HF trial

ME Nassif, SL Windsor, F Tang, Y Khariton, M Husain… - Circulation, 2019 - Am Heart Assoc
… In patients with heart failure and reduced ejection fraction, use of dapagliflozin over 12
weeks did not affect mean NT-proBNP but increased the proportion of patients experiencing …

Dapagliflozin in Patients with Chronic Heart Failure: A Systematic Review and Meta‐Analysis

R Cai, Y Xu, Q Su - Cardiology research and practice, 2021 - Wiley Online Library
… of dapagliflozin for the management of chronic heart failure. We showed that dapagliflozin
… significantly decrease the frequency of cardiovascular death/hospitalization for heart failure, …

Dapagliflozin: a review in symptomatic heart failure with reduced ejection fraction

HA Blair - American Journal of Cardiovascular Drugs, 2021 - Springer
heart failure with reduced ejection fraction (HFrEF). The cardiovascular (CV) benefits of
dapagliflozin were … Table 2 Efficacy of dapagliflozin in patients with symptomatic heart failure with …

Effects of dapagliflozin on biomarkers, symptoms and functional status in patients with heart failure with reduced ejection fraction with and without diabetes-the Define …

M Kosiborod, M Nassif, S Windsor, F Tang… - … of Cardiac Failure, 2019 - Elsevier
… Three large cardiovascular outcome trials of patients with type 2 diabetes (T2D) found a …
for heart failure (HF) in patients treated with SGLT2i. However, a majority of patients in these …

Impact of dapagliflozin on cardiac remodelling in patients with chronic heart failure: The DAPA‐MODA study

DA Pascual‐Figal, JL Zamorano… - … of Heart Failure, 2023 - Wiley Online Library
Dapagliflozin reduces the risk of de novo heart failure (HF) in diabetics, and it has shown to
improve the prognosis of patients with HF across all ranges of left ventricularcardiovascular

Effect of dapagliflozin on cardiac function in people with type 2 diabetes and albuminuria–A double blind randomized placebo-controlled crossover trial

MK Eickhoff, FJ Olsen, M Frimodt-Møller, LJ Diaz… - Journal of Diabetes and …, 2020 - Elsevier
… of heart failure (HF) and cardiovascular death in people with type 2 diabetes (T2D) and …
cardiovascular disease. Our aim was to examine the effect of the SGLT2i dapagliflozin on cardiac