Prediction of the effect of dapagliflozin on kidney and heart failure outcomes based on short-term changes in multiple risk markers

NMA Idzerda, BV Stefansson, MJ Pena… - Nephrology Dialysis …, 2020 - academic.oup.com
… effects on cardiovascular risk markers translate into … dapagliflozin to model the effect of
the drug on kidney and heart failure (HF) outcomes in patients with T2DM and impaired kidney

Differential effects of dapagliflozin on cardiovascular risk factors at varying degrees of renal function

S Petrykiv, CD Sjöström, PJ Greasley, J Xu… - Clinical Journal of the …, 2017 - journals.lww.com
… baseline risk marker, baseline risk marker-by-study interaction, and baseline … kidney
disease are needed to assess whether these risk marker changes, induced by dapagliflozin

Effects of dapagliflozin on circulating markers of phosphate homeostasis

MA de Jong, SI Petrykiv, GD Laverman… - Clinical Journal of the …, 2019 - journals.lww.com
… Furthermore, beneficial effects on other cardiovascular risk markers have been reported …
effects of dapagliflozin on phosphate homeostasis independent of its effect on kidney function. …

Effect of exenatide twice daily and dapagliflozin, alone and in combination, on markers of kidney function in obese patients with type 2 diabetes: a prespecified …

CC van Ruiten… - Diabetes, Obesity …, 2021 - Wiley Online Library
… Assessment of the separate and combined effects of dapagliflozin and exenatide on kidney
variables was a prespecified secondary objective of the DECREASE study. The main study …

Effects of the SGLT2 inhibitor dapagliflozin on proteinuria in non-diabetic patients with chronic kidney disease (DIAMOND): a randomised, double-blind, crossover trial

DZI Cherney, CCJ Dekkers, SJ Barbour… - The lancet Diabetes & …, 2020 - thelancet.com
… the kidney effects of the SGLT2 inhibitor dapagliflozin in patients with proteinuric kidney
The effects of long-term treatment with dapagliflozin on clinical kidney outcomes in patients …

Effects of dapagliflozin in patients with kidney disease, with and without heart failure

JJV McMurray, DC Wheeler, BV Stefánsson, N Jongs… - Heart Failure, 2021 - jacc.org
… The purpose of this paper was to investigate the effects of dapagliflozin in chronic kidney
Dapagliflozin reduced the risk of kidney failure and cardiovascular death/HF hospitalization …

Exposure–response relationships of dapagliflozin on cardiorenal risk markers and adverse events: a pooled analysis of 13 phase II/III trials

JV Koomen, J Stevens… - British Journal of Clinical …, 2020 - Wiley Online Library
risk markers. Our study offers a first assessment on the exposure–response relationship for
dapagliflozin for other cardiorenal risk markers … the risk for heart failure and kidney outcomes …

Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis …

DC Wheeler, BV Stefánsson, N Jongs… - The lancet Diabetes & …, 2021 - thelancet.com
… with chronic kidney disease. We aimed to investigate the effects of dapagliflozin on kidney,
… according to underlying cause of chronic kidney disease, reported as diabetic nephropathy, …

Effects of dapagliflozin in stage 4 chronic kidney disease

GM Chertow, P Vart, N Jongs, RD Toto… - Journal of the …, 2021 - journals.lww.com
… beneficial effects of dapagliflozin on kidney and cardiovascular … loss of kidney function as
reflected by the eGFR slopes over time. … developed kidney failure requiring dialysis or kidney

Reduction in albuminuria with dapagliflozin cannot be predicted by baseline clinical characteristics or changes in most other risk markers

HJL Heerspink, CD Sjöström… - Diabetes, Obesity …, 2019 - Wiley Online Library
Dapagliflozin, a selective sodium … risk markers, including body weight and blood
pressure.1, 2 Studies of SGLT2 inhibitors in patients with type 2 diabetes with and without kidney