Decreased neutralization of SARS-CoV-2 global variants by therapeutic anti-spike protein monoclonal antibodies

T Tada, BM Dcosta, H Zhou, A Vaill, W Kazmierski… - BioRxiv, 2021 - biorxiv.org
… the large decrease in neutralizing titer for REGN10933 on both variants combined with a
minor decrease in neutralizing titer by REGN10987 on both variants (Figure. 2 and Table. 1). …

mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants

K Wu, AP Werner, JI Moliva, M Koch, A Choi… - BioRxiv, 2021 - biorxiv.org
variants of 20E (EU1), 20A.EU2, D614G-N439, mink cluster 5, B.1.1.7, and B.1.351 variants,
we assessed the neutralizing … In contrast, a significant decrease in neutralizing titers was …

SARS‐CoV‐2 variants and vulnerability at the global level

VP Chavda, AB Patel… - Journal of medical …, 2022 - Wiley Online Library
… viral variants. This review encompasses the impact of identified variants on neutralizing
antibodies … generate antibodies with decreased neutralizing activity against beta variants. Overall …

Convalescent-phase sera and vaccine-elicited antibodies largely maintain neutralizing titer against global SARS-CoV-2 variant spikes

T Tada, BM Dcosta, MI Samanovic, RS Herati… - MBio, 2021 - Am Soc Microbiol
… , the variants were neutralized nearly as well as the wild-type pseudotyped virus. The B.1.351
variant … Whether the decreased neutralizing titer of the cocktail will translate into a loss of …

Serum neutralizing activity of mRNA-1273 against SARS-CoV-2 variants

A Choi, M Koch, K Wu, G Dixon, J Oestreicher… - Journal of …, 2021 - Am Soc Microbiol
… (Delta), showed significantly decreased neutralization titers ranging from 2.1-fold to 8.4-fold …
of SARS-CoV-2 that have been documented globally during the COVID-19 pandemic, it …

Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern

L Dupont, LB Snell, C Graham, J Seow, B Merrick… - Nature …, 2021 - nature.com
neutralization activity, differences in sera neutralization potency against SARS-CoV-2 and the
Alpha and Beta variants decreased… Owing to the rapid spread of B.1.617.2 globally and the …

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

D Planas, D Veyer, A Baidaliuk, I Staropoli… - Nature, 2021 - nature.com
… To contextualize the isolate of the Delta variant reported here, we inferred a global phylogeny
… With the Delta variant, neutralization titres were significantly decreased by four- to sixfold …

Emerging SARS-CoV-2 variants and impact in global vaccination programs against SARS-CoV-2/COVID-19

CE Gómez, B Perdiguero, M Esteban - Vaccines, 2021 - mdpi.com
… B.1.351 variant is notably more resistant to neutralization by … significant decrease in the
neutralization of B.1.351 variant by … decreases, the geometric mean of the neutralization titers in …

[HTML][HTML] Reduced neutralization of SARS-CoV-2 B. 1.617 by vaccine and convalescent serum

C Liu, HM Ginn, W Dejnirattisai, P Supasa, B Wang… - Cell, 2021 - cell.com
Neutralization of both viruses is reduced compared with ancestral Wuhan-related strains, …
in neutralization of B.1.617.2, suggesting that individuals infected previously by these variants

Neutralizing antibodies against SARS-CoV-2 variants induced by natural infection or vaccination: A systematic review and individual data meta-analysis

X Chen, Z Chen, AS Azman, R Sun, W Lu, N Zheng… - 2021 - papers.ssrn.com
Globally-threatening SARS-CoV-2 variants overshadow the … able to 69 neutralize some
emerging variants, and antibody-… infectivity and 110 decreased neutralizing potency, with …