Cognitive function of children with cystic fibrosis: deleterious effect of early malnutrition

RL Koscik, PM Farrell, MR Kosorok, KM Zaremba… - …, 2004 - publications.aap.org
Objective. Patients who have cystic fibrosis (CF) and experience delayed diagnosis by
traditional methods have greater nutritional insult compared with peers diagnosed via neonatal …

Airway inflammation in cystic fibrosis

A Elizur, CL Cannon, TW Ferkol - Chest, 2008 - Elsevier
… Treatments are currently being developed to minimize the deleterious effects of the
neutrophil without impairing host defenses against infection, since they are certainly involved in …

Deleterious impact of Pseudomonas aeruginosa on cystic fibrosis transmembrane conductance regulator function and rescue in airway epithelial cells

NTN Trinh, C Bilodeau, É Maillé… - European …, 2015 - Eur Respiratory Soc
… We also confirmed a deleterious impact of PsaDM on wt-CFTR currents in non-cystic fibrosis
… on the rescue of ΔF508-CFTR function induced by VRT-325 in primary cystic fibrosis cells. …

[HTML][HTML] Deleterious impact of hyperglycemia on cystic fibrosis airway ion transport and epithelial repair

C Bilodeau, O Bardou, É Maillé, Y Berthiaume… - … of Cystic Fibrosis, 2016 - Elsevier
… However, this effect did not appear to be mediated through a deleterious impact of HG on …
We also observed that HG elicited a less deleterious effect in CF primary airway cell …

Mechanisms of the noxious inflammatory cycle in cystic fibrosis

M Rottner, JM Freyssinet, MC Martínez - Respiratory research, 2009 - Springer
… Moreover, low levels of S-nitrosoglutathione, a physiological NO donor that acts as an
innate-immune mediator, can enhance the deleterious effects of Pseudomonas aeruginosa by …

Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

PM Quinton - The Lancet, 2008 - thelancet.com
… pH changes associated with altered HCO 3 − could have far-reaching and deleterious effects
in cystic fibrosis, but I propose that excessive Ca 2+ and H + ions remaining in mucus will …

The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

T Rosenow, LC Mok, L Turkovic… - European …, 2019 - Eur Respiratory Soc
… important clinical and prognostic markers of lung disease in cystic fibrosis (CF). However,
whether in … We aimed to determine whether their repeated detection has a deleterious effect on …

Increased oxidative stress induces apoptosis in human cystic fibrosis cells

M Rottner, S Tual-Chalot, HA Mostefai… - PloS one, 2011 - journals.plos.org
… Oxidative stress results in deleterious cell function in pathologies associated with … to the
isoforms of superoxide dismutases (SOD) in cystic fibrosis (CF) cells. Pro-apoptotic agents …

Repairing the basic defect in cystic fibrosis–one approach is not enough

CM Farinha, P Matos - The FEBS journal, 2016 - Wiley Online Library
Cystic fibrosis has attracted much attention in recent years due to significant advances in …
deficient functional expression of mutant cystic fibrosis transmembrane conductance regulator ( …

Absence of detrimental effect of the carrier state for the cystic fibrosis gene

WY Hallett, AG Knudson Jr… - American Review of …, 1965 - atsjournals.org
… If, as has been suggested (2-10), carriers of the cystic fibrosis · … effort to determine whether
cystic fibrosis heterozygotes are, in … produced no consequential deleterious effect in them. …