TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide

M Cetkovic-Cvrlje, DL Eizirik - Cytokine, 1994 - Elsevier
effects of cytokines on insulinproducing cells. In the present study we further characterized the
effects of IL-@, TNF-a and IFN-… The role of NO for the deleterious effects of combinations of …

[HTML][HTML] Harnessing mechanistic knowledge on beneficial versus deleterious IFN-I effects to design innovative immunotherapies targeting cytokine activity to specific …

E Tomasello, E Pollet, TP Vu Manh, G Uzé… - Frontiers in …, 2014 - frontiersin.org
deleterious IFN-I responses in selected diseases. Emphasis will be put on the potentially
deleterious functions of IFN… on the respective roles of IFN-I and IFN-III in promoting resolution of …

Deleterious role of IFNγ in a toxic model of central nervous system demyelination

P Maña, D Liñares, S Fordham, M Staykova… - The American journal of …, 2006 - Elsevier
… Taken together, our results suggest a deleterious role rather than a protective role for IFNγ
… of the source of IFNγ in our model, our results clearly support the deleterious role of IFNγ in …

Macrophage priming by interferon gamma: a selective process with potentially harmful effects

JG Williams, GJ Jurkovich, GB Hahnel… - Journal of leukocyte …, 1992 - academic.oup.com
… involved in both beneficial and deleterious effects of inflammation. The lymphokine
interferon-γ (IFN-γ) is capable of producing paradoxical immunoinflammatory effects. In the …

[HTML][HTML] Interferon-gamma (IFN-γ): Exploring its implications in infectious diseases

G Kak, M Raza, BK Tiwari - Biomolecular concepts, 2018 - degruyter.com
… ways to subvert the deleterious effects of IFN-γ. M. tb averts the activating effects of IFN-γ on
… Many crucial immune protective responses exerted by IFN-γ are inhibited by M. tb. Various …

The role of IFN-gamma in the pathology of experimental endotoxemia.

FP Heinzel - Journal of immunology (Baltimore, Md.: 1950), 1990 - journals.aai.org
… but comparatively little is known about the effect of IFN on the course of septic shock. Because
IFN-… a reasonable assumption is that the deleterious effect of IFN-y pretreatment is largely …

Probiotics and commensals reverse TNF-α–and IFN-γ–induced dysfunction in human intestinal epithelial cells

S Resta–Lenert, KE Barrett - Gastroenterology, 2006 - Elsevier
… Conclusions: Deleterious effects of TNF-α and IFN-γ on epithelial function are prevented
by probiotic, and to a lesser extent, commensal pretreatment. These data extend the spectrum …

Protection of human polymorphonuclear leukocyte function from the deleterious effects of isolation, irradiation, and storage by interferonγ and granulocyte‐colony …

JH Rex, SC Bhalla, DM Cohen, JP Hester… - …, 1995 - Wiley Online Library
… However, the effects on PMNs are not the only effects of … disease, we have examined the
effects of irradiation on PMN … cytokines (IFN-y and G-CSF) to modulate its deleterious effects. …

Oligodendroglial response to the immune cytokine interferon gamma

B Popko, KD Baerwald - Neurochemical research, 1999 - Springer
… In an effort to elucidate the mechanism by which IFN-7 exerts its deleterious effects on CNS
myelin, a number of studies have examined the response of purified CNS cells in culture to …

Heterogeneous effects of IFN-gamma in adjuvant arthritis.

CO Jacob, J Holoshitz, P Van der Meide… - … (Baltimore, Md.: 1950 …, 1989 - journals.aai.org
… of IFN-y (… IFN-y has been found to have deleterious effects in murine lupus nephritis (4)
and in patients with multiple sclerosis (5). Despite this, some clinical studies suggest that IFN-y …