Adeno-associated virus vector as a platform for gene therapy delivery

D Wang, PWL Tai, G Gao - Nature reviews Drug discovery, 2019 - nature.com
gene therapy is encouraging, we must acknowledge the limitations and challenges of this
gene delivery platform… and immunological barriers to delivery 25 . These challenges are being …

Exosomes as nano-theranostic delivery platforms for gene therapy

A Tan, J Rajadas, AM Seifalian - Advanced drug delivery reviews, 2013 - Elsevier
… exosome-based gene delivery can serve as a potent mechanism for gene transfection. Thus…
particular emphasis on its potential as a novel nanoscale delivery platform for gene therapy. …

[HTML][HTML] Viral vector platforms within the gene therapy landscape

JT Bulcha, Y Wang, H Ma, PWL Tai… - … and targeted therapy, 2021 - nature.com
… -based gene therapy landscape, we focus on these three highly regarded vector platforms
and … The key step in gene therapy is efficient gene delivery to the target tissue/cells, which is …

[HTML][HTML] State-of-the-art human gene therapy: part I. Gene delivery technologies

D Wang, G Gao - Discovery medicine, 2014 - ncbi.nlm.nih.gov
… -viral and viral gene delivery technology platforms. As cell-based gene therapy blossomed,
we also summarized the diverse types of cells and vectors employed in ex vivo gene transfer. …

[HTML][HTML] Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

N D'souza, F Rossignoli, G Golinelli, G Grisendi… - BMC medicine, 2015 - Springer
Regenerative medicine relying on cell and gene therapies is one of the most promising
approaches to repair tissues. Multipotent mesenchymal stem/stromal cells (MSC), a population of …

Gene therapy: Comprehensive overview and therapeutic applications

N Sayed, P Allawadhi, A Khurana, V Singh, U Navik… - Life sciences, 2022 - Elsevier
… , gene therapy has been wielded in a plethora of diseases. However, coherent and innocuous
delivery … In the past few years, gene therapy has evolved as a novel platform in the field of …

Gene therapy progress and prospects: hydrodynamic gene delivery

H Herweijer, JA Wolff - Gene therapy, 2007 - nature.com
… HLV delivery is a platform technology with equal efficiency in small and large research …
HTV gene delivery has been used to test gene therapy approaches for genetic and acquired …

Vector platforms for gene therapy of inherited retinopathies

I Trapani, A Puppo, A Auricchio - Progress in retinal and eye research, 2014 - Elsevier
… and consistent monitoring of the effects of gene delivery in both animal models and patients.
… to compare the effects of vector/gene delivery in one eye to disease progression in the …

Nanocarriers in gene therapy: a review

H Xu, Z Li, J Si - Journal of biomedical nanotechnology, 2014 - ingentaconnect.com
… The versatility of polymeric nanocarriers offers a significant advantage to gene delivery over
other nanocarrier platforms. Polymer matrices can be selected based on their utilities, allow…

Magnetic nanoparticles: Applications in gene delivery and gene therapy

S Majidi, F Zeinali Sehrig, M Samiei… - Artificial cells …, 2016 - Taylor & Francis
… For gene delivery, magnetic nanoparticles (MNPs) are typically combined with a delivery
platform to encapsulate the gene, and promote cell uptake. Delivery technologies that have …