Urinary titin is not an early biomarker of skeletal muscle atrophy induced by muscle denervation in mice

J Tanihata, S Minamisawa - PLoS One, 2023 - journals.plos.org
… Titin protein is also known to be cleaved by calpain and matrix-metalloproteinase-2 when
protease activity is increased in pathological conditions such as oxidative stress [28, 29]. …

Adipose‐derived stem cells delay muscle atrophy after peripheral nerve injury in the rodent model

BK Schilling, MA Schusterman, DY Kim… - Muscle & …, 2019 - Wiley Online Library
… of MMP-2, albeit sparse. The DiR-labeled ASCs did not appear to be localized to the presence
of either Ki67 or MMP-2 … A 2-week investigation of 3 ASC injections into the denervated rat …

Inhibiting Matrix Metalloproteinases Protects Evoked Electromyography Amplitudes and Muscle Tension in the Orbicularis Oris Muscle in a Rat Model of Facial Nerve …

S Wu, L Song, M Yu, C Gong… - Journal of Neuropathology …, 2022 - academic.oup.com
muscle injury (19) and MMP-2 plays a critical role in skeletal muscular atrophy; moreover,
inhibiting MMP-2 … Unlike the neurotransmission that is completely blocked after denervation, …

Renal denervation promotes atherosclerosis in hypertensive apolipoprotein E-deficient mice infused with angiotensin II

Y Wang, TN Dinh, A Nield, SM Krishna… - Frontiers in …, 2017 - frontiersin.org
… significantly increased the aortic mRNA expression of matrix metalloproteinase-2 (MMP-2). …
II associated with upregulation of MMP-2. The higher MMP-2 expression could be the results …

HuR mediates changes in the stability of AChR β-subunit mRNAs after skeletal muscle denervation

OR Joassard, G Bélanger, J Karmouch… - Journal of …, 2015 - Soc Neuroscience
2C), suggesting that HuR becomes enriched in the cytoplasm after … , we hypothesized
that p38 MAPK activation in denervated muscles could increase the stability of AChR β-subunit …

Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers

R Valle-Tenney, DL Rebolledo, KE Lipson, E Brandan - Matrix Biology, 2020 - Elsevier
… Western blot analysis of HIF-1α expression in denervated gastrocnemius muscles at 2, 4
days, 1 week and 2 weeks post denervation. Densitometric analysis of HIF-1α protein levels …

Osteoactivin attenuates skeletal muscle fibrosis after distraction osteogenesis by promoting extracellular matrix degradation/remodeling

I Tonogai, M Takahashi, K Yukata, R Sato… - Journal of Pediatric …, 2015 - journals.lww.com
mmp-3 and mmp-9 in fibroblasts within skeletal muscle in response to unloading conditions
such as denervation … upregulated at 2 weeks, and expressions of mmp-2 and mmp-8 in the …

Effects of stretching on the basement membrane structure in the soleus muscle of Wistar rats

Y Kanazawa, T Takahashi, T Higuchi, R Miyachi… - Medical Molecular …, 2023 - Springer
Matrix metalloproteinase 2 (MMP2) activity was evaluated by a gelatin zymography assay
(a… Matrix metalloproteinase 2 (MMP2) localization in the soleus muscle of the control (a, b), …

Biochemical insights into the role of matrix metalloproteinases in regeneration: challenges and recent developments

IH Bellayr, X Mu, Y Li - Future medicinal chemistry, 2009 - Taylor & Francis
… TIMP1 and 2 activity is dependent on the stage of muscle healing. … and MMP9 to repress
denervation-mediated fibrosis [73]. … Distinct patterns of MMP-9 and MMP-2 activity in slow and …

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia

R Sartori, A Hagg, S Zampieri, A Armani… - Science translational …, 2021 - science.org
… (D) Immunoblot and densitometric analysis of p-SMAD1/5/8 protein in TA muscles examined
2 weeks after transfection by electroporation with constructs expressing enhanced green …