Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-β

DL Rebolledo, D González, J Faundez-Contreras… - Matrix Biology, 2019 - Elsevier
… of denervation. These results suggest that in our model CTGF/CCN2 is not up-regulated by
canonical TGF-β signaling early after denervation and … following skeletal muscle denervation. …

Role of transforming growth factor-β1 in the process of fibrosis of denervated skeletal muscle

M Fanbin, C Jianghai, L Juan, W Yang… - Journal of Huazhong …, 2011 - Springer
… of TGF-β1 was increased significantly in denervated skeletal muscle, which might play a
crucial role during muscleTGF-β1 during fibrosis within denervated muscle, such that we may …

[HTML][HTML] Expression of TGF-β1 and CTGF is associated with fibrosis of denervated sternocleidomastoid muscles in mice

F Liu, W Tang, D Chen, M Li, Y Gao… - The Tohoku Journal of …, 2016 - jstage.jst.go.jp
… used sternocleidomastoid muscles instead of laryngeal muscles for denervation experiments…
that TGF-β1 and CTGF would also play a pivotal role in denervated skeletal muscle fibrosis. …

Skeletal muscle denervation: past, present and future

TY Kostrominova - International Journal of Molecular Sciences, 2022 - mdpi.com
denervated muscle. Muscle collagen breakdown is inhibited after denervation, leading to
collagen accumulation [9]… The activation of muscle stem cells (satellite cells) during prolonged …

The adaptive response of transforming growth factor-β2 and-βRII in the overloaded, regenerating and denervated muscles of rats

K Sakuma, K Watanabe, M Sano, S Kitajima… - Acta …, 2000 - Springer
… Our hypothesis is that the type of change in TGF-β and the receptors may differ in denervated
muscle compared to muscleTGFβ, known to affect matrix protein synthesis in a variety of …

HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle

X Yang, P Xue, X Liu, X Xu, Z Chen - Cell communication and signaling, 2018 - Springer
TGF-β1 was induced in denervated muscle and it could promote atrophy of skeletal muscle
… activity were also detected in denervated muscle and were further promoted by exogenous …

Electrical stimulation based on chronaxie increases fibrosis and modulates TWEAK/Fn14, TGF-β/myostatin, and MMP pathways in denervated muscles

CM Pinheiro-Dardis, TL Russo - American Journal of Physical …, 2017 - journals.lww.com
… fibrosis and accentuated muscle atrophy in denervated muscles. Although ES reduced the
accumulation of TWEAK and myostatin expressions, it up-regulated Fn14 and TGF-β in a time-…

Regulation of connective tissue remodeling in the early phase of denervation in a rat skeletal muscle

J Ozawa, T Kurose, S Kawamata, A Kaneguchi… - Biomedical …, 2013 - jstage.jst.go.jp
… In the present study, TGF-β1 expression was increased progressively in denervated muscles
with concomitant suppression of collagen mRNA expression. However, the suppression of …

Intermittent stretching induces fibrosis in denervated rat muscle

FM Faturi, RC Franco, D Gigo‐Benato, AC Turi… - Muscle & …, 2016 - Wiley Online Library
… applied to denervated muscles. We found that stretching activated MMP-9, TGF-β1, and …
of connective tissue, but did not avoid muscle fiber atrophy or induce sarcomerogenesis of …

The role of TGFβ1 during skeletal muscle regeneration

K Delaney, P Kasprzycka, MA Ciemerych… - Cell biology …, 2017 - Wiley Online Library
… Here, we present the role of TGF-β1 in myogenic differentiation and muscle repair. The …
of TGF-β family. In the response to the damage and denervation rat skeletal muscles show …