… set of OATP1B1 substrates, we explored this unexpected strong substrate dependence of the
… known OATP1B1 substrates, were used in addition to estrone-3-sulfate as the prototypical …

… Drug substrates for members of the human OATP family … –drug interactions, and the in vitro
analysis of the functional consequences of genetic variations in SLCO genes encoding OATP …

… Substrate-specific and/or time-dependent inhibition of transporters might be a possible
explanation for these discrepancies, as has been found previously for various inhibitors. All these …

… , none of the substrates was transported by the OATP1B1*18 … the OATP1B1 protein could
influence the substrate spectrum, … function were substrate- and cell-line dependent. The …

… OATP1B1 appears to be the most important, and variation of its … Besides being a substrate
of OATP1B1, pravastatin and … -dependent drug–drug interactions are well known for drug …

… As a large number of therapeutic reagents are substrates and/or inhibitors of OATP1B1
and … Substratedependent drug-drug interactions between gemfibrozil, fluvastatin and other …

… substrates, with consequent potential for reduced drug efficacy. As a result of extensive work
on GFJ-drug interactions … bioavailability of a number of OATP substrates (eg, fexofenadine, …

… widely prescribed classes of drugs are included in the list of OATP substrates, such as 3-…
inhibitory capacity of gemfibrozil has been reported to be substrate dependent Citation[57]. …

… broad substrate selectivity like OATP1B1 and 1B3. Substrates drugs of these OATPs are …
However, there is substrate/inhibitor dependence to the drug–FJ interaction. For example, …

… clinically observed drug-drug interactions attributable to … [organic anion transporting
polypeptides (OATPs)], or to … -dependent, transporter-mediated drug-drug interactions will be …