LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR

Y Xu, H Fang, Q Xu, C Xu, L Yang, C Huang - Cell Cycle, 2020 - Taylor & Francis
… Thus, our data provide a novel lncRNA GAS5 that could be a … In summary, our study
demonstrates that lncRNA GAS5 is down-… Our data provide a novel lncRNA GAS5 that could be a …

Silencing lncRNA GAS5 alleviates apoptosis and fibrosis in diabetic cardiomyopathy by targeting miR-26a/b-5p

C Zhu, H Zhang, D Wei, Z Sun - Acta diabetologica, 2021 - Springer
GAS5 may have diverse … GAS5 knockdown reversed the elevation of fibrosis-related
protein (α-SMA, collagen I and fibronectin) in cardiac tissues of diabetic mice, suggesting GAS5

Tcf3‐activated lncRNA Gas5 regulates newborn mouse cardiomyocyte apoptosis in diabetic cardiomyopathy

D Su, Y Ju, W Han, Y Yang, F Wang… - Journal of cellular …, 2020 - Wiley Online Library
… However, the function of lncRNA GAS5 in diabetic cardiomyopathy is still not clear. Thus, in
… the progression of the lncRNA GAS5 in diabetic cardiomyopathy. lncRNAs can function as …

GAS5 regulates diabetic cardiomyopathy via miR‑221‑3p/p27 axis‑associated autophagy

D Chen, M Zhang - Molecular medicine reports, 2021 - spandidos-publications.com
Diabetic cardiomyopathy (DCM) is one of the primary complications of the cardiovascular
system due to diabetes‑… lncRNA GAS5 has been revealed to be aberrantly increased in …

Long non-coding RNA: a key regulator in the pathogenesis of diabetic cardiomyopathy

Y Guo, X Feng, D Wang, X Kang, L Zhang… - Frontiers in …, 2021 - frontiersin.org
Gas5 on DCM is insufficient, the cardiac Gas5 could be a valuable target to improve DCM. …
of lncRNAs in the development of diabetic cardiomyopathy. We show a number of lncRNAs

[HTML][HTML] The interregulatory circuit between non-coding RNA and apoptotic signaling in diabetic cardiomyopathy

H Wu, Y Liu, C Liu - Non-coding RNA Research, 2024 - Elsevier
… The lncRNA known as growth arrest-specific 5 (GAS5) emerged as a … GAS5 was observed
to be elevated in both AC16 cardiomyocytes treated with HG and in a rat model of diabetic

LncRNA GAS5 downregulates NLRP3 inflammasome activation-mediated pyroptosis in sepsis-induced myocardial injury by targeting SIRT3/AMPKα

M Luo, Y Peng, D Lv, Y Xue, L Huang, Y Hu, W Zhu… - Heliyon, 2023 - cell.com
… differentially expression plays an important role in septic mice, and GAS5 could be a new …
in lncRNA GAS5 levels in the heart tissue of septic mice and the CLP + shGAS5 group. GAS5

The mechanisms of lncRNA GAS5 in cardiovascular cells and its potential as novel therapeutic target

X Jiang, Q Ning - Journal of Drug Targeting, 2020 - Taylor & Francis
GAS5 with pressure overload-induced cardiac … that GAS5 attenuated cardiac fibrosis in
mice by regulating PTEN/MMP-2. Those two studies demonstrated that GAS5 decreased cardiac

Unveiling the vital role of long non-coding RNAs in cardiac oxidative stress, cell death, and fibrosis in diabetic cardiomyopathy

Y Tian, Z Gao, W Liu, J Li, X Jiang, Y Xin - Antioxidants, 2022 - mdpi.com
… found that lncRNA GAS5 was significantly repressed in the cardiac tissue of diabetic rats;
GAS5 … IL-1β and IL-18 levels in HG-treated cardiac muscle cells (HL-1 cells). They showed that …

Knockdown of long noncoding RNA GAS5 protects human cardiomyocyte-like AC16 cells against high glucose-induced inflammation by inhibiting miR-21-5p …

J Zhao, B Liu, C Li - Naunyn-Schmiedeberg's archives of pharmacology, 2020 - Springer
diabetic patients. In this study, we aimed to identify the functional role of long noncoding RNA
GAS5Diabetic cardiomyopathy (DCM), characterized by cardiac remodeling and diastolic …