SARSCoV2 infection‐induced immune responses: Friends or foes?

K Li, Z Hao, X Zhao, J Du, Y Zhou - Scandinavian Journal of …, 2020 - Wiley Online Library
… increase of cytokines in COVID-19 patients. SARS-CoV-2 RNA and proteins interact with
various pattern recognition receptors that switch on antiviral immune responses to regulate viral …

SARS-CoV-2 induces cytokine responses in human basophils

SR Bonam, C Chauvin, L Levillayer… - Frontiers in …, 2022 - frontiersin.org
… Though the interaction of SARS-CoV-2 with various immune … from COVID-19 patients, we
observed that SARS-CoV-2 does … that basophil cytokine responses to SARS-CoV-2 might help …

Macrophages and dendritic cells are not the major source of pro-inflammatory cytokines upon SARS-CoV-2 infection

MA Niles, P Gogesch, S Kronhart… - Frontiers in …, 2021 - frontiersin.org
… The early immune response upon infection with SARS-CoV-2 and the … cytokine storm in
COVID-19 patients is not yet fully understood. Hence, we aim to uncover the role of different

[HTML][HTML] Dual nature of type I interferons in SARS-CoV-2-induced inflammation

C King, J Sprent - Trends in immunology, 2021 - cell.com
… expression of the receptors for these cytokines is different. Thus, whereas receptors for IFN-I
(… For IFN-I, these cytokines augment immune responses to viruses in several ways, namely …

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

T Patra, K Meyer, L Geerling, TS Isbell, DF Hoft… - PLoS …, 2020 - journals.plos.org
IL-6 secretion and other cytokines leading to a hyper-inflammatory response are in line with
COVID-19 … We propose that SARS-CoV-2 infection in pulmonary epithelial cells induces …

Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations

P Thepmankorn, J Bach, A Lasfar, X Zhao, S Souayah… - Cytokine, 2021 - Elsevier
… -19 patients, almost 10 times greater than the levels in other patients, and was associated
with increased mortality [97], [99]. Moreover, significantly higher levels of inflammatory and …

Interplay between SARS-CoV-2 and the type I interferon response

M Sa Ribero, N Jouvenet, M Dreux, S Nisole - PLoS pathogens, 2020 - journals.plos.org
… For example, the inducible negative regulators such as the suppressor of cytokine signaling
(SOCS1 and SOCS3) act at various levels of the Jak–STAT pathway or by targeting IRF7 for …

Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study

X Zhu, KA Gebo, AG Abraham, F Habtehyimer… - The Lancet …, 2023 - thelancet.com
… and chemokines play a critical role in the response to … association of COVID-19 vaccination
with cytokine and … the other cytokine concentrations were not significantly different between …

Variable induction of pro-inflammatory cytokines by commercial SARS CoV-2 spike protein reagents: potential impacts of LPS on in vitro modeling and pathogenic …

W Ouyang, T Xie, H Fang, C Gao, T Stantchev… - International journal of …, 2021 - mdpi.com
… glycan profiles differ between various commercial SARS CoV-2 spike protein-containing …
to cytokine responses induced by these proteins. Our finding that polymyxin B blocks cytokine

[HTML][HTML] Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes

MA Moreno-Eutimio, C Lopez-Macias… - Microbes and …, 2020 - Elsevier
different cytokine induction profiles. TLR7-specific agonists generally induce IFN-regulated
cytokines, but … to the production of proinflammatory cytokines [23]. These factors may provide …