… marker is physically close or in the vicinity of the genetic variant causing the disease, there
will be statistically significant evidence of linkage, as estimated by a statistic termed LOD …

… Third, human genetics is grounded in human biology, which is especially important for
neuropsychiatric phenotypes that may not be fully conserved across species. Finally, next-…

… We provide here an overview of the principal human genes known to … genetic studies is
also demonstrated by the strong impact of age at onset of disease on our ability to detect genetic …

… Over the last decade or so the human genetics field has debated the common disease–common
variant hypothesis, which posits that common complex traits are largely due to common …

… data from Lp(a) and cardiovascular disease. This approach was also used to … genetic
variants in the population makes Lp(a) the strongest genetic risk factor for cardiovascular disease …

… that have caused human genetic disease, with a view to providing a more complete picture
of how L1-mediated retrotransposition impacts upon the architecture of the human genome. …

… It has been argued that most of this failure is due to the inadequacies of preclinical models
of disease, and our lack of understanding of human biology [68]. Critically, human genetic …

… of genetic variations contributing to disease susceptibility, we performed a systems
genetics … We utilized a population of primary early passage human aortic endothelial cell (HAEC) …

… expression quantitative trait loci (eQTLs) in human cell-lines, primary cells, and … disease.
Here, we discuss how eQTLs have the potential to accelerate discovery of disease genes and …

… in the ability to link genes, and individual variants, to human disease traits. Genome-wide …
) on human disease traits. Below we review the current status of discovery in human genetics …